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| Isolation of isoflavones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea. | Hessler PE, Larsen PE, Constantinou AI, Schram KH, Weber JM. | Appl Microbiol Biotechnol | 1997 | Metabolism | metabolism, isolation & purification, metabolism | 10.1007/s002530050947 | 9163954 | Enzymology |
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| Nucleotide sequence of the ermE distal flank of the erythromycin biosynthesis cluster in Saccharopolyspora erythraea. | Pereda A, Summers R, Katz L. | Gene | 1997 | | genetics, biosynthesis, Bacterial Proteins, Genes, Bacterial, Multigene Family | 10.1016/s0378-1119(97)00086-3 | 9249068 | |
| Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production. | Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L. | Microbiology (Reading) | 1997 | Metabolism | genetics, metabolism, biosynthesis, biosynthesis, Genes, Bacterial, Multigene Family | 10.1099/00221287-143-10-3251 | 9353926 | |
| The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase. | Weissman KJ, Timoney M, Bycroft M, Grice P, Hanefeld U, Staunton J, Leadlay PF. | Biochemistry | 1997 | | biosynthesis, biosynthesis | 10.1021/bi971566b | 9374862 | |
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| Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. | Gaisser S, Bohm GA, Cortes J, Leadlay PF. | Mol Gen Genet | 1997 | | genetics, biosynthesis, Genes, Bacterial, Multigene Family | 10.1007/s004380050566 | 9393448 | |
| [Localization of rifampicin resistance determinants on genetic map of Saccharopolyspora erythraea]. | Nastasyak IN. | Antibiot Khimioter | 1997 | | genetics, pharmacology, pharmacology, genetics, genetics | | 9412406 | |
| Engineering broader specificity into an antibiotic-producing polyketide synthase. | Marsden AF, Wilkinson B, Cortes J, Dunster NJ, Staunton J, Leadlay PF. | Science | 1998 | Metabolism | analogs & derivatives, genetics, metabolism, biosynthesis, Protein Engineering | 10.1126/science.279.5348.199 | 9422686 | |
| The yersiniabactin biosynthetic gene cluster of Yersinia enterocolitica: organization and siderophore-dependent regulation. | Pelludat C, Rakin A, Jacobi CA, Schubert S, Heesemann J. | J Bacteriol | 1998 | | genetics, genetics, biosynthesis, Genes, Bacterial, Operon | 10.1128/jb.180.3.538-546.1998 | 9457855 | |
| Microbial conversion products of leptomycin B. | Kuhnt M, Bitsch F, Ponelle M, Sanglier JJ, Wang Y, Wolff B. | Appl Environ Microbiol | 1998 | Metabolism | metabolism, metabolism, metabolism, metabolism | 10.1128/aem.64.2.714-720.1998 | 9464413 | |
| The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea. | Pereda A, Summers RG, Stassi DL, Ruan X, Katz L. | Microbiology (Reading) | 1998 | Metabolism | genetics, metabolism, metabolism, genetics, genetics, genetics | 10.1099/00221287-144-2-543 | 9493390 | |
| Sonication-dependent electroporation of the erythromycin-producing bacterium Saccharopolyspora erythraea. | Fitzgerald NB, English RS, Lampel JS, Vanden Boom TJ. | Appl Environ Microbiol | 1998 | Metabolism | genetics, metabolism, biosynthesis, methods, Transformation, Genetic | 10.1128/aem.64.4.1580-1583.1998 | 9546194 | |
| Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea. | Salah-Bey K, Doumith M, Michel JM, Haydock S, Cortes J, Leadlay PF, Raynal MC. | Mol Gen Genet | 1998 | | genetics, Erythromycin, genetics, genetics, genetics, genetics, Bacterial Proteins | 10.1007/s004380050680 | 9563840 | |
| The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis. | Lomovskaya N, Doi-Katayama Y, Filippini S, Nastro C, Fonstein L, Gallo M, Colombo AL, Hutchinson CR. | J Bacteriol | 1998 | Metabolism | metabolism, biosynthesis, biosynthesis, metabolism, biosynthesis, Genes, Bacterial | 10.1128/jb.180.9.2379-2386.1998 | 9573189 | |
| Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. | Gaisser S, Bohm GA, Doumith M, Raynal MC, Dhillon N, Cortes J, Leadlay PF. | Mol Gen Genet | 1998 | Metabolism | genetics, metabolism, Genes, Fungal, Multigene Family | 10.1007/s004380050709 | 9613575 | |
| Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering. | Stassi DL, Kakavas SJ, Reynolds KA, Gunawardana G, Swanson S, Zeidner D, Jackson M, Liu H, Buko A, Katz L. | Proc Natl Acad Sci U S A | 1998 | | Macrolides, analogs & derivatives | 10.1073/pnas.95.13.7305 | 9636144 | |
| A genetically engineered strain of Saccharopolyspora erythraea that produces 6,12-dideoxyerythromycin A as the major fermentation product. | Stassi D, Post D, Satter M, Jackson M, Maine G. | Appl Microbiol Biotechnol | 1998 | Metabolism | genetics, metabolism, analogs & derivatives, biosynthesis, Genetic Engineering | 10.1007/s002530051238 | 9684306 | |
| Improved erythromycin production in a genetically engineered industrial strain of Saccharopolyspora erythraea. | Minas W, Brunker P, Kallio PT, Bailey JE. | Biotechnol Prog | 1998 | | genetics, biosynthesis, methods | 10.1021/bp980055t | 9694676 | |
| Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension. | Bohm I, Holzbaur IE, Hanefeld U, Cortes J, Staunton J, Leadlay PF. | Chem Biol | 1998 | | chemical synthesis, Protein Engineering | 10.1016/s1074-5521(98)90157-0 | 9710562 | |
| Construction of new vectors for high-level expression in actinomycetes. | Rowe CJ, Cortes J, Gaisser S, Staunton J, Leadlay PF. | Gene | 1998 | Enzymology | enzymology, genetics, genetics | 10.1016/s0378-1119(98)00327-8 | 9714812 | |
| Physical-genetic map of the erythromycin-producing organism Saccharopolyspora erythraea. | Reeves AR, Post DA, Vanden Boom TJ | Microbiology (Reading) | 1998 | Metabolism | Base Composition, Chromosomes, Bacterial/chemistry, Deoxyribonucleases, Type II Site-Specific/genetics, Erythromycin/*biosynthesis, *Restriction Mapping/methods, Saccharopolyspora/*genetics/metabolism | 10.1099/00221287-144-8-2151 | 9720036 | |
| Denitrification by actinomycetes and purification of dissimilatory nitrite reductase and azurin from Streptomyces thioluteus. | Shoun H, Kano M, Baba I, Takaya N, Matsuo M. | J Bacteriol | 1998 | Metabolism | metabolism, metabolism, metabolism, metabolism | 10.1128/jb.180.17.4413-4415.1998 | 9721277 | |
| Insertion sequences. | Mahillon J, Chandler M. | Microbiol Mol Biol Rev | 1998 | | DNA Transposable Elements | 10.1128/mmbr.62.3.725-774.1998 | 9729608 | |
| Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin. | Fernandez E, Weissbach U, Sanchez Reillo C, Brana AF, Mendez C, Rohr J, Salas JA. | J Bacteriol | 1998 | Metabolism | genetics, biosynthesis, genetics, metabolism, biosynthesis, Genes, Bacterial | 10.1128/jb.180.18.4929-4937.1998 | 9733697 | |
| ErmE methyltransferase recognition elements in RNA substrates. | Vester B, Nielsen AK, Hansen LH, Douthwaite S. | J Mol Biol | 1998 | Metabolism | metabolism, metabolism | 10.1006/jmbi.1998.2024 | 9735285 | |
| hrcA, encoding the repressor of the groEL genes in Streptomyces albus G, is associated with a second dnaJ gene. | Grandvalet C, Rapoport G, Mazodier P. | J Bacteriol | 1998 | | genetics, genetics, genetics, genetics, genetics | 10.1128/jb.180.19.5129-5134.1998 | 9748446 | |
| Enzymatic conversion of glucose to UDP-4-keto-6-deoxyglucose in Streptomyces spp. | Liu SY, Rosazza JP. | Appl Environ Microbiol | 1998 | Metabolism | metabolism, biosynthesis, analogs & derivatives, metabolism, analogs & derivatives | 10.1128/aem.64.10.3972-3976.1998 | 9758828 | |
| Genetic engineering of an industrial strain of Saccharopolyspora erythraea for stable expression of the Vitreoscilla haemoglobin gene (vhb). | Brunker P, Minas W, Kallio PT, Baile JE. | Microbiology (Reading) | 1998 | | genetics, genetics, genetics, genetics, Genes, Bacterial | 10.1099/00221287-144-9-2441 | 9782491 | |
| Biosynthesis of the Pseudomonas polyketide coronafacic acid requires monofunctional and multifunctional polyketide synthase proteins. | Rangaswamy V, Jiralerspong S, Parry R, Bender CL. | Proc Natl Acad Sci U S A | 1998 | Metabolism | enzymology, genetics, metabolism, genetics, metabolism | 10.1073/pnas.95.26.15469 | 9860992 | Enzymology |
| Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene. | Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR. | J Bacteriol | 1999 | Metabolism | genetics, metabolism, biosynthesis, genetics, metabolism, genetics, metabolism, genetics, metabolism, genetics, metabolism, Genes, Bacterial | 10.1128/jb.181.1.305-318.1999 | 9864344 | |
| The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster. | Lombo F, Brana AF, Mendez C, Salas JA. | J Bacteriol | 1999 | | Chromosomes, Bacterial, genetics, biosynthesis, genetics, Trans-Activators, genetics, Repetitive Sequences, Nucleic Acid, Genes, Regulator, Multigene Family | 10.1128/jb.181.2.642-647.1999 | 9882681 | |
| Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity. | Pacey MS, Dirlam JP, Geldart RW, Leadlay PF, McArthur HA, McCormick EL, Monday RA, O'Connell TN, Staunton J, Winchester TJ | J Antibiot (Tokyo) | 1998 | Phylogeny | Anti-Bacterial Agents/chemistry/*isolation & purification/*pharmacology, Erythromycin/*analogs & derivatives/chemistry/*isolation & purification/*pharmacology, Fermentation, Microbial Sensitivity Tests, Saccharopolyspora, Structure-Activity Relationship | 10.7164/antibiotics.51.1029 | 9918396 | Enzymology |
| ErmE methyltransferase recognizes features of the primary and secondary structure in a motif within domain V of 23 S rRNA. | Villsen ID, Vester B, Douthwaite S. | J Mol Biol | 1999 | Metabolism | metabolism, metabolism, chemistry, chemistry, Nucleic Acid Conformation | 10.1006/jmbi.1998.2504 | 9973557 | |
| Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. | McDaniel R, Thamchaipenet A, Gustafsson C, Fu H, Betlach M, Ashley G. | Proc Natl Acad Sci U S A | 1999 | Metabolism | analogs & derivatives, chemical synthesis, genetics, metabolism, methods | 10.1073/pnas.96.5.1846 | 10051557 | |
| Reactor heterogeneity with saccharopolyspora erythraea airlift fermentations | Pollard DJ, Ison AP, Shamlou PA, Lilly MD. | Biotechnol Bioeng | 1998 | | | 10.1002/(sici)1097-0290(19980605)58:5<453::aid-bit1>3.0.co;2-c | 10099281 | |
| Structural elucidation of a novel erythromycin, 13-cyclopentyl-13-desethyl-erythromycin B, from a recombinant Saccharopolyspora erythraea strain, NRRL 2338 pIG/1. | Parsons IC, Everett JR, Pacey MS, Ruddock JC, Swanson AG, Thompson CM. | J Antibiot (Tokyo) | 1999 | Metabolism | genetics, metabolism, analogs & derivatives, chemistry | 10.7164/antibiotics.52.190 | 10344576 | |
| [Isolation and characterization of Saccharopolyspora erythraea mutants, resistant to chloramphenicol]. | Nastasiak IN, Zavorotnaia SA, Fedorenko VA, Danilenko VN. | Antibiot Khimioter | 1999 | Pathogenicity | drug effects, pharmacology, pharmacology | | 10382030 | |
| Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908. | Pelzer S, Sussmuth R, Heckmann D, Recktenwald J, Huber P, Jung G, Wohlleben W. | Antimicrob Agents Chemother | 1999 | | genetics, analogs & derivatives, biosynthesis, Genes, Bacterial, Multigene Family | 10.1128/aac.43.7.1565 | 10390204 | |
| Identification of site-specific recombination genes int and xis of the Rhizobium temperate phage 16-3. | Semsey S, Papp I, Buzas Z, Patthy A, Orosz L, Papp PP. | J Bacteriol | 1999 | | virology, genetics, genetics, genetics, Viral Proteins, Recombination, Genetic, Genes, Viral | 10.1128/jb.181.14.4185-4192.1999 | 10400574 | |
| Functional analysis of the carbohydrate-binding domains of Erwinia chrysanthemi Cel5 (Endoglucanase Z) and an Escherichia coli putative chitinase. | Simpson HD, Barras F. | J Bacteriol | 1999 | Enzymology | enzymology, metabolism, chemistry, metabolism, chemistry, enzymology | 10.1128/jb.181.15.4611-4616.1999 | 10419961 | Metabolism |
| Some structural features of an insoluble alpha-D-glucan from a mutant strain of Leuconostoc mesenteroides NRRL B-1355. | Cote GL, Ahlgren JA, Smith MR. | J Ind Microbiol Biotechnol | 1999 | Metabolism | metabolism, chemistry | 10.1038/sj.jim.2900678 | 10455497 | |
| The Effect of Rapeseed Oil Uptake on the Production of Erythromycin and Triketide Lactone by Saccharopolyspora erythraea. | Mirjalili N, Zormpaidis V, Leadlay PF, Ison AP. | Biotechnol Prog | 1999 | | | 10.1021/bp990099h | 10514261 | |
| Dispensable ribosomal resistance to spiramycin conferred by srmA in the spiramycin producer Streptomyces ambofaciens. | Pernodet JL, Gourmelen A, Blondelet-Rouault MH, Cundliffe E. | Microbiology (Reading) | 1999 | Pathogenicity | drug effects, Macrolides, biosynthesis, pharmacology, genetics, genetics, pharmacology | 10.1099/00221287-145-9-2355 | 10517588 | |
| Novel macrolides through genetic engineering. | Katz L, McDaniel R. | Med Res Rev | 1999 | | chemical synthesis, methods | 10.1002/(sici)1098-1128(199911)19:6<543::aid-med5>3.0.co;2-z | 10557369 | |
| Transcriptional organization of the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea. | Reeves AR, English RS, Lampel JS, Post DA, Vanden Boom TJ. | J Bacteriol | 1999 | | genetics, biosynthesis, Transcription, Genetic, Multigene Family | 10.1128/jb.181.22.7098-7106.1999 | 10559177 | |
| Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643. | Brown MS, Dirlam JP, McArthur HA, McCormick EL, Morse BK, Murphy PA, O'Connell TN, Pacey M, Rescek DM, Ruddock J, Wax RG. | J Antibiot (Tokyo) | 1999 | Metabolism | metabolism, Macrolides, analogs & derivatives, metabolism, pharmacology, chemistry | 10.7164/antibiotics.52.742 | 10580387 | |
| A unique chitinase with dual active sites and triple substrate binding sites from the hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1. | Tanaka T, Fujiwara S, Nishikori S, Fukui T, Takagi M, Imanaka T | Appl Environ Microbiol | 1999 | Enzymology | Amino Acid Sequence, Base Sequence, Binding Sites, Chitinases/*chemistry/genetics/*metabolism, Cloning, Molecular, Genomic Library, Hot Temperature, Kinetics, Molecular Sequence Data, Mutagenesis, Polymerase Chain Reaction, Pyrococcus/*enzymology/genetics, Recombinant Proteins/chemistry/isolation & purification/metabolism, Sequence Alignment, Sequence Deletion, Sequence Homology, Amino Acid, Substrate Specificity | 10.1128/AEM.65.12.5338-5344.1999 | 10583986 | Metabolism |
| Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2). | Rodri Guez E, Gramajo H. | Microbiology (Reading) | 1999 | | genetics, genetics, Genes, Bacterial | 10.1099/00221287-145-11-3109 | 10589718 | |
| Interspecies complementation in Saccharopolyspora erythraea : elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives. | Doumith M, Legrand R, Lang C, Salas JA, Raynal MC. | Mol Microbiol | 1999 | Metabolism | genetics, metabolism, genetics, analogs & derivatives, biosynthesis, Genes, Bacterial | 10.1046/j.1365-2958.1999.01666.x | 10594828 | |
| NMR assignments, secondary structure, and global fold of calerythrin, an EF-hand calcium-binding protein from Saccharopolyspora erythraea. | Aitio H, Annila A, Heikkinen S, Thulin E, Drakenberg T, Kilpelainen I. | Protein Sci | 1999 | | chemistry, chemistry, chemistry | 10.1110/ps.8.12.2580 | 10631973 | |
| Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein. | Liu W, Shen B. | Antimicrob Agents Chemother | 2000 | | genetics, genetics, Aminoglycosides, genetics, genetics, biosynthesis, Antigens, Bacterial, biosynthesis | 10.1128/aac.44.2.382-392.2000 | 10639366 | |
| Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus. | Lozano MJ, Remsing LL, Quiros LM, Brana AF, Fernandez E, Sanchez C, Mendez C, Rohr J, Salas JA. | J Biol Chem | 2000 | Metabolism | metabolism, biosynthesis, Methyltransferases | 10.1074/jbc.275.5.3065 | 10652287 | |
| Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. | Wilkinson B, Foster G, Rudd BA, Taylor NL, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Bohm IU, Rowe CJ, Cortes J, Leadlay PF, Staunton J. | Chem Biol | 2000 | | genetics, biosynthesis, chemistry | 10.1016/s1074-5521(00)00076-4 | 10662692 | |
| Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity. | Cupp-Vickery J, Anderson R, Hatziris Z. | Proc Natl Acad Sci U S A | 2000 | | chemistry, chemistry | 10.1073/pnas.97.7.3050 | 10716705 | |
| Semi-constant-time HMSQC (SCT-HMSQC-HA) for the measurement of (3)J(H(N))(H(alpha)) couplings in (15)N-labeled proteins. | Aitio H, Permi P. | J Magn Reson | 2000 | | chemistry, methods | 10.1006/jmre.1999.2010 | 10729265 | |
| Characterization of a 12-kilodalton rhodanese encoded by glpE of Escherichia coli and its interaction with thioredoxin. | Ray WK, Zeng G, Potters MB, Mansuri AM, Larson TJ. | J Bacteriol | 2000 | Metabolism | enzymology, metabolism, Escherichia coli Proteins, metabolism, metabolism | 10.1128/jb.182.8.2277-2284.2000 | 10735872 | Enzymology |
| Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. | Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L. | Antimicrob Agents Chemother | 2000 | | genetics, biosynthesis, Multigene Family | 10.1128/aac.44.5.1214-1222.2000 | 10770754 | |
| A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. | Gaisser S, Reather J, Wirtz G, Kellenberger L, Staunton J, Leadlay PF. | Mol Microbiol | 2000 | Metabolism | genetics, metabolism, biosynthesis, biosynthesis | 10.1046/j.1365-2958.2000.01856.x | 10792725 | |
| Studies on the interaction of fermentation and microfiltration operations: erythromycin recovery from Saccharopolyspora erythraea fermentation broths. | Davies JL, Baganz F, Ison AP, Lye GJ. | Biotechnol Bioeng | 2000 | Metabolism | metabolism, biosynthesis | 10.1002/1097-0290(20000820)69:4<429::aid-bit9>3.0.co;2-5 | 10862681 | |
| Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699. | Doi-Katayama Y, Yoon YJ, Choi CY, Yu TW, Floss HG, Hutchinson CR. | J Antibiot (Tokyo) | 2000 | Metabolism | metabolism, biosynthesis, metabolism, biosynthesis, Peptide Chain Elongation, Translational | 10.7164/antibiotics.53.484 | 10908112 | |
| Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin. | Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R. | J Antibiot (Tokyo) | 2000 | | biosynthesis, genetics, genetics, biosynthesis | 10.7164/antibiotics.53.502 | 10908114 | |
| Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea. | Volchegursky Y, Hu Z, Katz L, McDaniel R. | Mol Microbiol | 2000 | Metabolism | metabolism, metabolism, metabolism, metabolism | 10.1046/j.1365-2958.2000.02059.x | 10972798 | |
| Symbiosis-specific expression of Rhizobium etli casA encoding a secreted calmodulin-related protein. | Xi C, Schoeters E, Vanderleyden J, Michiels J. | Proc Natl Acad Sci U S A | 2000 | | Rhizobium, Plants, genetics, genetics | 10.1073/pnas.210181097 | 10995485 | |
| Analysis of genes involved in 6-deoxyhexose biosynthesis and transfer in Saccharopolyspora erythraea. | Doumith M, Weingarten P, Wehmeier UF, Salah-Bey K, Benhamou B, Capdevila C, Michel JM, Piepersberg W, Raynal MC. | Mol Gen Genet | 2000 | Metabolism | genetics, metabolism, biosynthesis, Bacterial Proteins, biosynthesis, Genes, Bacterial | 10.1007/s004380000329 | 11129052 | |
| Use of direct-infusion electrospray mass spectrometry to guide empirical development of improved conditions for expression of secondary metabolites from actinomycetes. | Zahn JA, Higgs RE, Hilton MD. | Appl Environ Microbiol | 2001 | Metabolism | growth & development, metabolism, methods | 10.1128/aem.67.1.377-386.2001 | 11133469 | |
| Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. | Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C. | Science | 2001 | | genetics, genetics, biosynthesis, genetics, Bacterial Proteins | 10.1126/science.1058092 | 11230695 | |
| Characterization of apo and partially saturated states of calerythrin, an EF-hand protein from S. erythraea: a molten globule when deprived of Ca(2+). | Aitio H, Laakso T, Pihlajamaa T, Torkkeli M, Kilpelainen I, Drakenberg T, Serimaa R, Annila A. | Protein Sci | 2001 | Metabolism | chemistry, metabolism, chemistry, EF Hand Motifs | 10.1110/ps.31201 | 11266596 | |
| Strength of mid-logarithmic and stationary phase Saccharopolyspora erythraea hyphae during a batch fermentation in defined nitrate-limited medium. | Stocks SM, Thomas CR. | Biotechnol Bioeng | 2001 | Metabolism | growth & development, metabolism | 10.1002/bit.1070 | 11320507 | |
| Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. | Wilson DJ, Xue Y, Reynolds KA, Sherman DH. | J Bacteriol | 2001 | Metabolism | metabolism, Macrolides, metabolism, genetics, genetics, biosynthesis, Genes, Regulator | 10.1128/jb.183.11.3468-3475.2001 | 11344155 | |
| Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase. | Rowe CJ, Bohm IU, Thomas IP, Wilkinson B, Rudd BA, Foster G, Blackaby AP, Sidebottom PJ, Roddis Y, Buss AD, Staunton J, Leadlay PF. | Chem Biol | 2001 | Enzymology | isolation & purification, biosynthesis, genetics, metabolism, isolation & purification, genetics | 10.1016/s1074-5521(01)00024-2 | 11358694 | Phylogeny |
| Control of directionality in integrase-mediated recombination: examination of recombination directionality factors (RDFs) including Xis and Cox proteins. | Lewis JA, Hatfull GF. | Nucleic Acids Res | 2001 | Metabolism | metabolism, Recombination, Genetic | 10.1093/nar/29.11.2205 | 11376138 | |
| Chromosome topology and genome size of selected actinomycetes species. | Redenbach M, Scheel J, Schmidt U. | Antonie Van Leeuwenhoek | 2000 | Genetics | genetics, genetics, Genome, Bacterial | 10.1023/a:1010289326752 | 11386344 | |
| Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosa. | Madduri K, Waldron C, Merlo DJ. | J Bacteriol | 2001 | Enzymology | enzymology, Macrolides, biosynthesis, genetics, metabolism | 10.1128/jb.183.19.5632-5638.2001 | 11544225 | Metabolism |
| New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster. | Gaisser S, Lill R, Wirtz G, Grolle F, Staunton J, Leadlay PF. | Mol Microbiol | 2001 | Metabolism | enzymology, analogs & derivatives, biosynthesis, metabolism, metabolism, biosynthesis | 10.1046/j.1365-2958.2001.02594.x | 11555300 | Enzymology |
| Characterization of a Brucella species 25-kilobase DNA fragment deleted from Brucella abortus reveals a large gene cluster related to the synthesis of a polysaccharide. | Vizcaino N, Cloeckaert A, Zygmunt MS, Fernandez-Lago L. | Infect Immun | 2001 | | genetics, genetics, biosynthesis, analysis, Sequence Deletion, Genes, Bacterial, Multigene Family | 10.1128/iai.69.11.6738-6748.2001 | 11598046 | |
| Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins. | Carreras C, Frykman S, Ou S, Cadapan L, Zavala S, Woo E, Leaf T, Carney J, Burlingame M, Patel S, Ashley G, Licari P. | J Biotechnol | 2002 | Metabolism | metabolism, analogs & derivatives, metabolism | 10.1016/s0168-1656(01)00372-8 | 11689246 | |
| Viability, strength, and fragmentation of Saccharopolyspora erythraea in submerged fermentation. | Stocks SM, Thomas CR. | Biotechnol Bioeng | 2001 | | physiology, Fermentation | 10.1002/bit.10017 | 11745148 | |
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| Genetic and proteomic characterization of rpoB mutations and their effect on nematicidal activity in Photorhabdus luminescens LN2. | Qiu X, Yan X, Liu M, Han R. | PLoS One | 2012 | | microbiology, genetics, Rifampin, genetics, genetics, genetics, genetics | 10.1371/journal.pone.0043114 | 22912803 | |
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| Kinetic, mutational, and structural analysis of malonate semialdehyde decarboxylase from Coryneform bacterium strain FG41: mechanistic implications for the decarboxylase and hydratase activities. | Guo Y, Serrano H, Poelarends GJ, Johnson WH, Hackert ML, Whitman CP. | Biochemistry | 2013 | Enzymology | enzymology, metabolism, Mutation | 10.1021/bi400567a | 23781927 | Metabolism |
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| A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. | Guo J, Zhang X, Luo S, He F, Chen Z, Wen Y, Li J. | PLoS One | 2013 | Metabolism | genetics, metabolism, analogs & derivatives, genetics, metabolism, genetics, metabolism | 10.1371/journal.pone.0071330 | 23967193 | |
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| Genomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide Pathway. | Stulberg ER, Lozano GL, Morin JB, Park H, Baraban EG, Mlot C, Heffelfinger C, Phillips GM, Rush JS, Phillips AJ, Broderick NA, Thomas MG, Stabb EV, Handelsman J. | Front Microbiol | 2016 | | Cycloheximide, Bioinformatics, Natural Product Biosynthesis, Glutaramide Antibiotics, Hygromycin A, Neutramycin | 10.3389/fmicb.2016.00573 | 27199910 | |
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| Whole genome sequencing for deciphering the resistome of Chryseobacterium indologenes, an emerging multidrug-resistant bacterium isolated from a cystic fibrosis patient in Marseille, France. | Cimmino T, Rolain JM. | New Microbes New Infect | 2016 | Genetics | Urease, Carotenoid, Resistome, Polyketide Synthase, Microbial Genomics, Chryseobacterium Indologenes, Nonribosomal Polyketide Synthase | 10.1016/j.nmni.2016.03.006 | 27222716 | |
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| A Phenotypic and Genotypic Analysis of the Antimicrobial Potential of Cultivable Streptomyces Isolated from Cave Moonmilk Deposits. | Maciejewska M, Adam D, Martinet L, Naome A, Calusinska M, Delfosse P, Carnol M, Barton HA, Hayette MP, Smargiasso N, De Pauw E, Hanikenne M, Baurain D, Rigali S. | Front Microbiol | 2016 | Metabolism | Geomicrobiology, secondary metabolism, Genome Mining, Mlsa Phylogeny, Cryptic Antibiotics | 10.3389/fmicb.2016.01455 | 27708627 | Genetics |
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| A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes. | Allhorn M, Arve S, Bruggemann H, Lood R. | Sci Rep | 2016 | Metabolism | microbiology, isolation & purification, metabolism, metabolism, metabolism | 10.1038/srep36412 | 27805044 | Enzymology |
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| Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. | Schorn MA, Alanjary MM, Aguinaldo K, Korobeynikov A, Podell S, Patin N, Lincecum T, Jensen PR, Ziemert N, Moore BS. | Microbiology (Reading) | 2016 | Metabolism | genetics, isolation & purification, metabolism, microbiology, Genome, Bacterial | 10.1099/mic.0.000386 | 27902408 | Enzymology |
| Development of an Improved System for the Generation of Knockout Mutants of Amycolatopsis sp. Strain ATCC 39116. | Meyer F, Pupkes H, Steinbuchel A. | Appl Environ Microbiol | 2017 | | Vanillin, Gene deletion, vanillic acid, Genetic modification, metabolic engineering, actinomycetes, Guaiacol, Amycolatopsis, genetics, genetics, Gene Deletion, methods | 10.1128/aem.02660-16 | 27913417 | |
| Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. | Chenge JT, Duyet LV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW. | J Biol Chem | 2017 | Enzymology | Mycobacterium tuberculosis, mass spectrometry (MS), Enzyme structure, high throughput screening (HTS), Cytochrome p450, Electron Paramagnetic Resonance (Epr), Redox Potentiometry, Cyp126a1, enzymology, chemistry, chemistry, antagonists & inhibitors, chemistry, chemistry, chemistry | 10.1074/jbc.m116.748822 | 27932461 | |
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| Acetyl-CoA synthetases of Saccharopolyspora erythraea are regulated by the nitrogen response regulator GlnR at both transcriptional and post-translational levels. | You D, Wang MM, Ye BC. | Mol Microbiol | 2017 | Enzymology | enzymology, metabolism, genetics, genetics, Transcription, Genetic, Gene Expression Regulation, Bacterial, Protein Processing, Post-Translational | 10.1111/mmi.13595 | 27987242 | Metabolism |
| Chromosomal position effect influences the heterologous expression of genes and biosynthetic gene clusters in Streptomyces albus J1074. | Bilyk B, Horbal L, Luzhetskyy A. | Microb Cell Fact | 2017 | | heterologous expression, Chromosomal Position Effect, Streptomyces Albus J1074, Chromosomes, Bacterial, genetics, Gene Expression Regulation, Bacterial | 10.1186/s12934-016-0619-z | 28052753 | |
| Genome Analysis of Two Pseudonocardia Phylotypes Associated with Acromyrmex Leafcutter Ants Reveals Their Biosynthetic Potential. | Holmes NA, Innocent TM, Heine D, Bassam MA, Worsley SF, Trottmann F, Patrick EH, Yu DW, Murrell JC, Schiott M, Wilkinson B, Boomsma JJ, Hutchings MI. | Front Microbiol | 2016 | Genetics | Antibiotics, actinomycetes, Nystatin, Pseudonocardia, Genome Mining, Acromyrmex, Polyene, Leafcutter Ants | 10.3389/fmicb.2016.02073 | 28082956 | |
| Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering. | Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ. | ACS Chem Biol | 2017 | Metabolism | enzymology, metabolism, metabolism, metabolism, Mutagenesis, Site-Directed, metabolism | 10.1021/acschembio.6b00732 | 28103677 | Enzymology |
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| Rifampicin-Resistance Mutations in the rpoB Gene in Bacillus velezensis CC09 have Pleiotropic Effects. | Cai XC, Xi H, Liang L, Liu JD, Liu CH, Xue YR, Yu XY. | Front Microbiol | 2017 | | Mutation, RNA polymerase, Rifampicin Resistance, Iturin A, Bacillus Velezensis | 10.3389/fmicb.2017.00178 | 28243227 | |
| Strain improvement and optimization studies for enhanced production of erythromycin in bagasse based medium using Saccharopolyspora erythraea MTCC 1103. | Subathra Devi C, Saini A, Rastogi S, Jemimah Naine S, Mohanasrinivasan V | 3 Biotech | 2013 | Biotechnology | | 10.1007/s13205-013-0186-5 | 28324355 | |
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| Characterization of a Novel Nicotine Degradation Gene Cluster ndp in Sphingomonas melonis TY and Its Evolutionary Analysis. | Wang H, Zhi XY, Qiu J, Shi L, Lu Z. | Front Microbiol | 2017 | | Nicotine, Pathway Evolution, Pathway Distribution, Sphingomonas Melonis Ty, Ndp Gene Cluster | 10.3389/fmicb.2017.00337 | 28337179 | |
| Regulation of Sporangium Formation by BldD in the Rare Actinomycete Actinoplanes missouriensis. | Mouri Y, Konishi K, Fujita A, Tezuka T, Ohnishi Y. | J Bacteriol | 2017 | Metabolism | Gene regulation, Transcriptional factor, Regulon, Rare Actinomycete, Sporangium Formation, genetics, growth & development, metabolism, Gene Expression Regulation, Bacterial, growth & development | 10.1128/jb.00840-16 | 28348024 | |
| Actinoplanes Swims into the Molecular Age. | Buttner MJ. | J Bacteriol | 2017 | | Differentiation, Transcriptional regulation, Sporulation, motility, Filamentous Growth, C-di-gmp Signaling, genetics, Gene Expression Regulation, Bacterial | 10.1128/jb.00070-17 | 28348027 | |
| Establishment of the Inducible Tet-On System for the Activation of the Silent Trichosetin Gene Cluster in Fusarium fujikuroi. | Janevska S, Arndt B, Baumann L, Apken LH, Mauriz Marques LM, Humpf HU, Tudzynski B. | Toxins (Basel) | 2017 | Metabolism | Fungi, Biosynthesis, Gene regulation, secondary metabolism, Fusarium Fujikuroi, Pks-nrps, genetics, Pyrrolidinones, Gene Expression Regulation, Fungal | 10.3390/toxins9040126 | 28379186 | |
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| Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization. | Lowell AN, DeMars MD, Slocum ST, Yu F, Anand K, Chemler JA, Korakavi N, Priessnitz JK, Park SR, Koch AA, Schultz PJ, Sherman DH. | J Am Chem Soc | 2017 | Metabolism | metabolism, analogs & derivatives, metabolism, biosynthesis, metabolism | 10.1021/jacs.7b02875 | 28525276 | |
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| De Novo Biosynthesis of Apigenin, Luteolin, and Eriodictyol in the Actinomycete Streptomyces albus and Production Improvement by Feeding and Spore Conditioning. | Marin L, Gutierrez-Del-Rio I, Yague P, Manteca A, Villar CJ, Lombo F. | Front Microbiol | 2017 | | Flavonoid, Antioxidant, Flavone, Polyphenol, Anti-inflammatory, flavanone, Nutraceutical | 10.3389/fmicb.2017.00921 | 28611737 | |
| Discovery of Lysine Hydroxylases in the Clavaminic Acid Synthase-Like Superfamily for Efficient Hydroxylysine Bioproduction. | Hara R, Yamagata K, Miyake R, Kawabata H, Uehara H, Kino K. | Appl Environ Microbiol | 2017 | Metabolism | Bioconversion, Hydroxylases, Hydroxylation, Dioxygenases, L-lysine, Hydroxylysine, Clavaminic Acid Synthase-like Superfamily, enzymology, metabolism, metabolism, metabolism | 10.1128/aem.00693-17 | 28667106 | Enzymology |
| A Highly Efficient CRISPR-Cas9-Mediated Large Genomic Deletion in Bacillus subtilis. | So Y, Park SY, Park EH, Park SH, Kim EJ, Pan JG, Choi SK. | Front Microbiol | 2017 | Genetics | Bacillus subtilis, Gene insertion, Genome Engineering, Crispr-cas9, Large Genomic Deletion, Genomic Point Mutation | 10.3389/fmicb.2017.01167 | 28690606 | |
| 4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of gamma-glutamyltranspeptidase homolog for C-C bond cleavage. | Zhong G, Zhao Q, Zhang Q, Liu W. | Nat Commun | 2017 | Metabolism | enzymology, metabolism, metabolism, metabolism | 10.1038/ncomms16109 | 28706296 | Enzymology |
| Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus via metabolic engineering. | Gao W, Wu Z, Sun J, Ni X, Xia H. | PLoS One | 2017 | Metabolism | metabolism, analogs & derivatives, biosynthesis, Biosynthetic Pathways, methods | 10.1371/journal.pone.0181971 | 28753625 | |
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| The Skin Bacterium Propionibacterium acnes Employs Two Variants of Hyaluronate Lyase with Distinct Properties. | Nazipi S, Stodkilde-Jorgensen K, Scavenius C, Bruggemann H. | Microorganisms | 2017 | | Glycosaminoglycan, Extracellular matrix, Hyaluronic acid, Propionibacterium Acnes, Hyaluronate Lyase, Skin Microbiota | 10.3390/microorganisms5030057 | 28895889 | |
| Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76. | Gubbens J, Wu C, Zhu H, Filippov DV, Florea BI, Rigali S, Overkleeft HS, van Wezel GP. | ACS Chem Biol | 2017 | Metabolism | metabolism, metabolism, metabolism, metabolism | 10.1021/acschembio.7b00597 | 28945067 | |
| Development of Transcription Factor-Based Designer Macrolide Biosensors for Metabolic Engineering and Synthetic Biology. | Kasey CM, Zerrad M, Li Y, Cropp TA, Williams GJ. | ACS Synth Biol | 2018 | Metabolism | metabolism, metabolism, Biosensing Techniques, methods, Metabolic Engineering | 10.1021/acssynbio.7b00287 | 28950701 | |
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| The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis. | Hou B, Lin Y, Wu H, Guo M, Petkovic H, Tao L, Zhu X, Ye J, Zhang H. | J Bacteriol | 2018 | Metabolism | Streptomyces, Lincomycin, Regulatory Protein, Cluster-situated Regulator, Lmbu Homologues, Lmbu, genetics, metabolism, biosynthesis, metabolism, Gene Expression Regulation, Bacterial | 10.1128/jb.00447-17 | 29038257 | |
| Morphology engineering of Streptomyces coelicolor M145 by sub-inhibitory concentrations of antibiotics. | Wang H, Zhao G, Ding X. | Sci Rep | 2017 | Metabolism | metabolism, cytology, drug effects, pharmacology, pharmacology | 10.1038/s41598-017-13493-y | 29038577 | Pathogenicity |
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| A systematic study of the whole genome sequence of Amycolatopsis methanolica strain 239T provides an insight into its physiological and taxonomic properties which correlate with its position in the genus. | Tang B, Xie F, Zhao W, Wang J, Dai S, Zheng H, Ding X, Cen X, Liu H, Yu Y, Zhou H, Zhou Y, Zhang L, Goodfellow M, Zhao GP. | Synth Syst Biotechnol | 2016 | Genetics | AOS, AMS, Complete genome sequence, One Carbon Metabolism, Ats, Amycolatopsis Methanolica, Sub-generic Phyletic Clades | 10.1016/j.synbio.2016.05.001 | 29062941 | Metabolism |
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| Carbon Allocation in Rhodococcus jostii RHA1 in Response to Disruption and Overexpression of nlpR Regulatory Gene, Based on 13C-labeling Analysis. | Hernandez MA, Gleixner G, Sachse D, Alvarez HM. | Front Microbiol | 2017 | Metabolism | Regulation, Rhodococcus, lipid metabolism, 13C-glucose, Rha1, Nlpr | 10.3389/fmicb.2017.01992 | 29075252 | |
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| Overproduction of Erythromycin by Ultraviolet Mutagenesis and Expression of ermE Gene in Saccharopolyspora erythraea. | Fallahpour N, Adnani S, Rassi H, Asli E. | Assay Drug Dev Technol | 2017 | | UV mutagenesis, Saccharopolyspora erythraea, erythromycin, Tylosin Resistance Mutant, biosynthesis, biosynthesis, genetics, Ultraviolet Rays, Gene Expression Regulation, Bacterial, Mutagenesis | 10.1089/adt.2017.802 | 29120674 | |
| New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant. | Zhang S, Zhu J, Zechel DL, Jessen-Trefzer C, Eastman RT, Paululat T, Bechthold A. | Chembiochem | 2018 | Metabolism | Biosynthesis, Mutagenesis, Antimalarial Activity, P450 monooxygenase, Dehydrotyrosine, Annimycin, genetics, metabolism, pharmacology, pharmacology, biosynthesis, pharmacology, pharmacology, pharmacology, Mutation | 10.1002/cbic.201700428 | 29148157 | |
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| Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria. | Shi J, Feng Z, Xu J, Li F, Zhang Y, Wen A, Wang F, Song Q, Wang L, Cui H, Tong S, Chen P, Zhu Y, Zhao G, Wang S, Feng Y, Lin W. | Proc Natl Acad Sci U S A | 2023 | | Mycobacterium tuberculosis, Crystal structure, Glnr, Cryo-em Structure, Glnr-dependent Transcription Activation Complex (Glnr-tac), Actinobacteria | 10.1073/pnas.2300282120 | 37216560 | |
| Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery. | Yang Y, Kessler MGC, Marchan-Rivadeneira MR, Han Y, Han Y. | Molecules | 2023 | Genetics | Antibiotics, Natural products, Antimicrobial resistance, Genome Mining, Biosynthesis Gene Clusters, Biological Products, Anti-Bacterial Agents | 10.3390/molecules28104183 | 37241928 | |
| A meet-up of acetyl phosphate and c-di-GMP modulates BldD activity for development and antibiotic production. | Fu Y, Dong YQ, Shen JL, Yin BC, Ye BC, You D. | Nucleic Acids Res | 2023 | | Saccharopolyspora, Anti-Bacterial Agents | 10.1093/nar/gkad494 | 37283056 | |
| Heterologous Expression of the Formicamycin Biosynthetic Gene Cluster Unveils Glycosylated Fasamycin Congeners. | McDonald HP, Alford A, Devine R, Hems ES, Nepogodiev SA, Arnold CJ, Rejzek M, Stanley-Smith A, Holmes NA, Hutchings MI, Wilkinson B. | J Nat Prod | 2023 | | Streptomyces coelicolor, Galactose | 10.1021/acs.jnatprod.3c00052 | 37327570 | |
| Ammonium sulfate supplementation enhances erythromycin biosynthesis by augmenting intracellular metabolism and precursor supply in Saccharopolyspora erythraea. | Yuan Y, Xu F, Ke X, Lu J, Huang M, Chu J. | Bioprocess Biosyst Eng | 2023 | | Metabolic flux analysis, Saccharopolyspora erythraea, Ammonium sulfate, Targeted Metabolomics, Erythromycin Production, Cellular Metabolic Mechanism, Saccharopolyspora | 10.1007/s00449-023-02898-x | 37392219 | |
| Identification and characterization of a strong constitutive promoter stnYp for activating biosynthetic genes and producing natural products in streptomyces. | Guo W, Xiao Z, Huang T, Zhang K, Pan HX, Tang GL, Deng Z, Liang R, Lin S. | Microb Cell Fact | 2023 | | Streptomyces, Natural products, heterologous expression, Biosynthetic gene cluster, Constitutive Promoter, Stnyp, Streptomyces, Biological Products | 10.1186/s12934-023-02136-9 | 37443029 | |
| Role of fourteen XRE-DUF397 pairs from Streptomyces coelicolor as regulators of antibiotic production and differentiation. New players in a complex regulatory network. | Riascos C, Martinez-Carrasco A, Diaz M, Santamaria RI. | Front Microbiol | 2023 | | Streptomyces, Morphological differentiation, Antibiotic Production, Duf397, Xenobiotic Regulator Response (Xre) | 10.3389/fmicb.2023.1217350 | 37492264 | |
| Bioactive Metabolites from Terrestrial and Marine Actinomycetes. | Ngamcharungchit C, Chaimusik N, Panbangred W, Euanorasetr J, Intra B. | Molecules | 2023 | Genetics | Biodiversity, Bioactive metabolites, actinomycetes, Genome Mining, Silent Gene Activation, Actinobacteria, Biological Products, Anti-Infective Agents | 10.3390/molecules28155915 | 37570885 | |
| Metagenomic analysis of soybean endosphere microbiome to reveal signatures of microbes for health and disease. | Chouhan U, Gamad U, Choudhari JK. | J Genet Eng Biotechnol | 2023 | Genetics | Taxonomy, Function, Metagenomics, Endospheric Mg-rast, Omicbox | 10.1186/s43141-023-00535-4 | 37584775 | |
| Priestia megaterium Metabolism: Isolation, Identification of Naringenin Analogues and Genes Elevated Associated with Nanoparticle Intervention. | Al-Theyab NS, Abuelizz HA, Al-Hamoud GA, Aldossary A, Liang M. | Curr Issues Mol Biol | 2023 | Transcriptome | drug discovery, gold nanoparticles, Transcriptome Analysis, Biosynthetic Pathways, Priestia Megaterium, Naringenin Analogues | 10.3390/cimb45080424 | 37623243 | |
| Streptomyces iakyrus TA 36 as First-Reported Source of Quinone Antibiotic gamma-Rubromycin. | Charousova I, Hlebova M, Hleba L, Medo J, Wink J. | Molecules | 2023 | Phylogeny | Soil, Streptomyces, 16S rRNA, ?-rubromycin, Streptomyces, Quinones | 10.3390/molecules28165977 | 37630229 | |
| Flow-cytometric cell sorting coupled with UV mutagenesis for improving pectin lyase expression. | Fang K, Ma J, Wang X, Xu Z, Zhang Z, Li P, Wang R, Wang J, Sun C, Dong Z. | Front Bioeng Biotechnol | 2023 | | Flow cytometry, Expression, UV mutagenesis, Escherichia Coli, Pectin Lyase | 10.3389/fbioe.2023.1251342 | 37720319 | |
| Integrated meta-omics approaches reveal Saccharopolyspora as the core functional genus in huangjiu fermentations. | Liu S, Zhang ZF, Mao J, Zhou Z, Zhang J, Shen C, Wang S, Marco ML, Mao J. | NPJ Biofilms Microbiomes | 2023 | | Saccharopolyspora | 10.1038/s41522-023-00432-1 | 37726290 | |
| How Combined Macrolide Nanomaterials are Effective Against Resistant Pathogens? A Comprehensive Review of the Literature. | Siraj EA, Yayehrad AT, Belete A. | Int J Nanomedicine | 2023 | | Drug resistance, Macrolides, Nanomedicine, Macrolide Nano-Delivery, Nanostructures, Metal Nanoparticles | 10.2147/ijn.s418588 | 37732155 | |
| An improved Lodderomyces elongisporus NRRL YB-4239 genome assembly substantiated by its electrophoretic karyotype. | Hoyer LL, Hogan EK, Freeman BA, Walden KKO, Hernandez AG. | Microbiol Resour Announc | 2023 | Genetics | Karyotype, Yeast, Genome sequence | 10.1128/mra.00596-23 | 37772887 | |
| Unveiling the Secrets of Calcium-Dependent Proteins in Plant Growth-Promoting Rhizobacteria: An Abundance of Discoveries Awaits. | Agaras BC, Grossi CEM, Ulloa RM. | Plants (Basel) | 2023 | | Calcium, Plant growth-promoting rhizobacteria, CaBP, Ca2+ Channels, Ca2+ Pumps | 10.3390/plants12193398 | 37836138 | |
| Characterization of Silver Carbonate Nanoparticles Biosynthesized Using Marine Actinobacteria and Exploring of Their Antimicrobial and Antibiofilm Activity. | Messaoudi O, Benamar I, Azizi A, Albukhaty S, Khane Y, Sulaiman GM, Salem-Bekhit MM, Hamdi K, Ghoummid S, Zoukel A, Messahli I, Kerchich Y, Benaceur F, Salem MM, Bendahou M. | Mar Drugs | 2023 | Phylogeny | Isolation, Antimicrobial, Antibiofilm, Marine Actinobacteria, Saccharopolyspora Erythrea, Silver Carbonate Nanoparticles, Actinobacteria, Anti-Infective Agents, Metal Nanoparticles | 10.3390/md21100536 | 37888471 | |
| Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster. | Eckert N, Rebets Y, Horbal L, Zapp J, Herrmann J, Busche T, Muller R, Kalinowski J, Luzhetskyy A. | Microb Cell Fact | 2023 | | Streptomyces, Antibiotic, Gene cluster, Strain Engineering, Transcriptional Refactoring, Biological Products, Polyketides | 10.1186/s12934-023-02231-x | 37964282 | |
| Transcriptional regulation of the fidaxomicin gene cluster and cellular development in Actinoplanes deccanensis YP-1 by the pleiotropic regulator MtrA. | Xie H, Ruan J-Y, Bu Q-T, Li Y-P, Su Y-T, Zhao Q-W, Du Y-L, Li Y-Q. | Microbiol Spectr | 2023 | Transcriptome | Protein-DNA interaction, Transcriptome, morphological development, two-component system, Fidaxomicin, Mtra, Industrial Actinomycetes, ATP-Binding Cassette Transporters, Gene Expression Regulation, Bacterial | 10.1128/spectrum.02702-23 | 37966201 | Biotechnology |
| The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking. | Grasekamp KP, Beaud Benyahia B, Taib N, Audrain B, Bardiaux B, Rossez Y, Izadi-Pruneyre N, Lejeune M, Trivelli X, Chouit Z, Guerardel Y, Ghigo JM, Gribaldo S, Beloin C. | Nat Commun | 2023 | | Phospholipids, Escherichia coli Proteins | 10.1038/s41467-023-43411-y | 37993432 | |
| Comparative genomics of the niche-specific plant pathogen Streptomyces ipomoeae reveal novel genome content and organization. | Soares NR, Huguet-Tapia JC, Guan D, Clark CA, Yang K-T, Kluchka OR, Thombal RS, Kartika R, Badger JH, Pettis GS. | Appl Environ Microbiol | 2023 | | Streptomyces, Plant pathogens, Thaxtomin, Streptomyces, Solanum tuberosum | 10.1128/aem.00308-23 | 38009923 | |
| Research progress on GlnR-mediated regulation in Actinomycetes. | Gao B, Li G, Gu D, Wang J. | Front Microbiol | 2023 | | Metabolic regulation, actinomycetes, Cross-regulation, Global Regulator, Glnr | 10.3389/fmicb.2023.1282523 | 38075861 | |
| An atypical two-component system, AtcR/AtcK, simultaneously regulates the biosynthesis of multiple secondary metabolites in Streptomyces bingchenggensis. | Yan Y-S, Zou L-S, Wei H-G, Yang M-Y, Yang Y-Q, Li X-F, Xia H-Y. | Appl Environ Microbiol | 2024 | | Nanchangmycin, two-component system, Strain Engineering, Milbemycins, Streptomyces Bingchenggensis, Rewiring Regulatory Network, Streptomyces, Ethers, Macrolides, Spiro Compounds | 10.1128/aem.01300-23 | 38112424 | |
| Analysis and review of techniques and tools based on machine learning and deep learning for prediction of lysine malonylation sites in protein sequences. | Ramazi S, Tabatabaei SAH, Khalili E, Nia AG, Motarjem K. | Database (Oxford) | 2024 | | Lysine, Deep Learning | 10.1093/database/baad094 | 38245002 | |
| An inducible CRISPRi circuit for tunable dynamic regulation of gene expression in Saccharopolyspora erythraea. | Jiang X, Ke X, Tian X, Chu J. | Biotechnol Lett | 2024 | | Saccharopolyspora erythraea, Inducible promoter, Crispri, Dynamic Regulation, Saccharopolyspora | 10.1007/s10529-023-03462-z | 38279045 | |
| The ssgB gene is required for the early stages of sporangium formation in Actinoplanes missouriensis. | Akutsu T, Tezuka T, Maruko M, Hirata A, Ohnishi Y. | J Bacteriol | 2024 | | FtsZ, Actinoplanes Missouriensis, Ssga-like Proteins, Sporangium Formation, Ssgb, Streptomyces, Streptomyces coelicolor, Actinobacteria, Actinoplanes | 10.1128/jb.00428-23 | 38353530 | |
| Unveiling the microbial communities and metabolic pathways of Keem, a traditional starter culture, through whole-genome sequencing. | Rana B, Chandola R, Sanwal P, Joshi GK. | Sci Rep | 2024 | | Microbiota | 10.1038/s41598-024-53350-3 | 38369518 | |
| Antimicrobial Residue Accumulation Contributes to Higher Levels of Rhodococcus equi Carrying Resistance Genes in the Environment of Horse-Breeding Farms. | Higgins C, Cohen ND, Slovis N, Boersma M, Gaonkar PP, Golden DR, Huber L. | Vet Sci | 2024 | | Rhodococcus equi, Antimicrobial Pollution, Antimicrobial Resistance Selection And Maintenance, Antimicrobial-resistant Bacterial Population Dynamics | 10.3390/vetsci11020092 | 38393110 | |
| Efficacy of powdered alfalfa leaves to ameliorate the toxic effects of aflatoxin B1 in turkey poults. | Nava-Ramirez MJ, Maguey-Gonzalez JA, Gomez-Rosales S, Hernandez-Ramirez JO, Latorre JD, Du X, Lopez-Coello C, Hargis BM, Tellez-Isaias G, Vazquez-Duran A, Mendez-Albores A. | Mycotoxin Res | 2024 | | Histology, Performance, adsorption, Aflatoxin B1, Turkey Poults, Powdered Alfalfa Leaves, Turkeys, Medicago sativa, Plant Leaves, Aflatoxin B1, Animal Feed | 10.1007/s12550-024-00527-4 | 38421516 | |
| Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2. | Bagde SR, Kim CY. | Nat Prod Rep | 2024 | | Polyketide Synthases, Cryoelectron Microscopy | 10.1039/d3np00060e | 38501175 | |
| The global nitrogen regulator GlnR is a direct transcriptional repressor of the key gluconeogenic gene pckA in actinomycetes. | Liu X, Wang X, Shao Z, Dang J, Wang W, Liu C, Wang J, Yuan H, Zhao G. | J Bacteriol | 2024 | | Actinomycete, gluconeogenesis, Pcka, Glnr, Nitrogen, Bacterial Proteins, Gene Expression Regulation, Bacterial, Gluconeogenesis | 10.1128/jb.00003-24 | 38606980 | |
| Improving the production of carbamoyltobramycin by an industrial Streptoalloteichus tenebrarius through metabolic engineering. | Feng Y, Jiang Y, Chen X, Zhu L, Xue H, Wu M, Yang L, Yu H, Lin J. | Appl Microbiol Biotechnol | 2024 | | Biosynthesis, Oxygenase, carbamoyltobramycin, Apramycin, Transcriptional Regulator, Lrp/asnc, Actinobacteria, Actinomycetales, Metabolic Engineering | 10.1007/s00253-024-13141-2 | 38643456 | |
| Two strategies to improve the supply of PKS extender units for ansamitocin P-3 biosynthesis by CRISPR-Cas9. | Guo S, Sun X, Li R, Zhang T, Hu F, Liu F, Hua Q. | Bioresour Bioprocess | 2022 | | Bidirectional Promoters, Actinosynnema Pretiosum, Extender Unit, Ansamitocin P-3 (Ap-3) | 10.1186/s40643-022-00583-7 | 38647752 | |
| Structure and Mechanisms of Assembly-Line Polyketide Synthases. | Soohoo AM, Cogan DP, Brodsky KL, Khosla C. | Annu Rev Biochem | 2024 | | Polyketide, Polyketide Synthase, Multifunctional Enzyme, Catalytic Cycle, Vectorial Biosynthesis, Polyketide Synthases, Catalytic Domain | 10.1146/annurev-biochem-080923-043654 | 38663033 | |
| Allosteric regulation by c-di-AMP modulates a complete N-acetylglucosamine signaling cascade in Saccharopolyspora erythraea. | You D, Zhao LC, Fu Y, Peng ZY, Chen ZQ, Ye BC. | Nat Commun | 2024 | | Saccharopolyspora, Acetylglucosamine, Bacterial Proteins, Dinucleoside Phosphates, Signal Transduction, Gene Expression Regulation, Bacterial | 10.1038/s41467-024-48063-0 | 38714645 | |
| Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity. | Harper CP, Day A, Tsingos M, Ding E, Zeng E, Stumpf SD, Qi Y, Robinson A, Greif J, Blodgett JAV. | Appl Environ Microbiol | 2024 | Phylogeny | Phylogeny, Polycyclic Tetramate Macrolactams, Biosynthetic Gene Clusters, Comparative Metabologenomics, Phylogeny, Multigene Family | 10.1128/aem.00600-24 | 38771054 | Genetics |
| Enhancing erythromycin production in Saccharopolyspora erythraea through rational engineering and fermentation refinement: A Design-Build-Test-Learn approach. | Shao M, Xu F, Ke X, Huang M, Chu J. | Biotechnol J | 2024 | | Saccharopolyspora erythraea, Ammonium sulfate, Systematic Metabolic Engineering, Erythromycin Production, Saccharopolyspora, Erythromycin, Fermentation, Metabolic Engineering | 10.1002/biot.202400039 | 38797723 | |
| Effects of the pleiotropic regulator DasR on lincomycin production in Streptomyces lincolnensis. | Pai H, Liu Y, Zhang C, Su J, Lu W. | Appl Microbiol Biotechnol | 2024 | Transcriptome | Lincomycin, Transcriptome Analysis, Transcriptional Regulators, Dasr, S. Lincolnensis, Streptomyces, Lincomycin, Anti-Bacterial Agents, Gene Expression Regulation, Bacterial | 10.1007/s00253-024-13201-7 | 38878095 | |
| Volatile communication in Actinobacteria: a language for secondary metabolism regulation. | Cuervo L, Mendez C, Salas JA, Olano C, Malmierca MG. | Microb Cell Fact | 2024 | Metabolism | Metabolites, Antibiotic, Streptomyces sp., Actinobacteria, Volatile compounds, secondary metabolism, Biosynthetic Potential, Actinobacteria, Volatile Organic Compounds, Secondary Metabolism | 10.1186/s12934-024-02456-4 | 38890640 | |
| Engineering of a TetR family transcriptional regulator BkdR enhances heterologous spinosad production in Streptomyces albus B4 chassis. | Wang W, Tang H, Cui X, Wei W, Wu J, Ye B-C. | Appl Environ Microbiol | 2024 | | heterologous expression, spinosad, Acetate Assimilation, Precursor Supply, Tetr Family Transcriptional Regulator, Propionate Assimilation, Streptomyces Albus B4, Streptomyces, Macrolides, Bacterial Proteins, Drug Combinations | 10.1128/aem.00838-24 | 38904409 | |
| Fluorometric Analysis of Carrier-Protein-Dependent Biosynthesis through a Conformationally Sensitive Solvatochromic Pantetheinamide Probe. | Miyada MG, Choi Y, Stepanauskas R, Woyke T, La Clair JJ, Burkart MD. | ACS Chem Biol | 2024 | | Fluorescent Dyes | 10.1021/acschembio.4c00169 | 38909314 | |
| Bioinformatic prediction of the stereoselectivity of modular polyketide synthase: an update of the sequence motifs in ketoreductase domain. | Xiang C, Yao S, Wang R, Zhang L. | Beilstein J Org Chem | 2024 | Enzymology | Bioinformatics, Stereocontrol, Polyketide Synthase, Conserved Motifs, Ketoreductase | 10.3762/bjoc.20.131 | 38978744 | |
| A network of acetyl phosphate-dependent modification modulates c-di-AMP homeostasis in Actinobacteria. | Fu Y, Zhao L-C, Shen J-L, Zhou S-Y, Yin B-C, Ye B-C, You D. | mBio | 2024 | | Acetylation, Actinobacteria, ACP, C-di-amp, Disa, Bacterial Proteins, Dinucleoside Phosphates, Gene Expression Regulation, Bacterial, Homeostasis | 10.1128/mbio.01411-24 | 38980040 | |
| Age-specific composition of milk microbiota in Tibetan sheep and goats. | Cao X, Fang Y, Bandan P, Suo L, Jiacuo G, Wu Y, Cuoji A, Zhuoga D, Chen Y, Ji, Quzhen C, Zhang K. | Appl Microbiol Biotechnol | 2024 | Phylogeny | Milk composition, Ruminant, lactobacillus, colostrum, Milk Microbiota, Milk, Goats, RNA, Ribosomal, 16S, Microbiota | 10.1007/s00253-024-13252-w | 38980443 | |
| Engineering Streptomyces albus B4 for Enhanced Production of (R)-Mellein: A High-Titer Heterologous Biosynthesis Approach. | Tang H, Wei W, Wu J, Cui X, Wang W, Qian T, Wo J, Ye BC. | J Agric Food Chem | 2024 | | Biosynthesis, heterologous expression, metabolic engineering, Precursor Supply, Streptomyces Albus B4, Streptomyces, Polyketide Synthases, Bacterial Proteins, Metabolic Engineering | 10.1021/acs.jafc.4c02463 | 39045837 | |
| How c-di-GMP controls progression through the Streptomyces life cycle. | Gallagher KA, Tschowri N, Brennan RG, Schumacher MA, Buttner MJ. | Curr Opin Microbiol | 2024 | | Streptomyces, Spores, Bacterial, Bacterial Proteins, Cyclic GMP, Gene Expression Regulation, Bacterial | 10.1016/j.mib.2024.102516 | 39059031 | |
| The Role of Wastewater Treatment Plants in Dissemination of Antibiotic Resistance: Source, Measurement, Removal and Risk Assessment. | Drane K, Sheehan M, Whelan A, Ariel E, Kinobe R. | Antibiotics (Basel) | 2024 | | Environmental pollution, Horizontal gene transfer, Antimicrobial resistance, Membrane bioreactor, Mobile genetic elements, One Health, Sewage Processing | 10.3390/antibiotics13070668 | 39061350 | |
| CRISPR/Cas9-Mediated Promoter Engineering in Saccharopolyspora erythraea. | Zhang Y, Qi H, Wang M. | Methods Mol Biol | 2024 | Genetics | Saccharopolyspora erythraea, erythromycin, Genome Editing, Crispr/cas9, Promoter Engineering, Saccharopolyspora, Promoter Regions, Genetic, CRISPR-Cas Systems, Gene Editing | 10.1007/978-1-0716-4063-0_8 | 39068336 | |
| Heterologous activation and metabolites identification of the pks7 gene cluster from Saccharopolyspora erythraea. | Tang H, Yang X, Wang W, Cui X, Wei W, Wu J, Sun P, Ye BC. | Synth Syst Biotechnol | 2024 | | Flavonoid, Saccharopolyspora erythraea, heterologous expression, 6-Ethylsalicyclic Acid, 6-Ethylsalicyclic Acid Ester Derivatives, 6-Methylsalicyclic Acid | 10.1016/j.synbio.2024.05.004 | 39099750 | |
| The acetyltransferase SCO0988 controls positively specialized metabolism and morphological differentiation in the model strains Streptomyces coelicolor and Streptomyces lividans. | Bi Y, An H, Chi Z, Xu Z, Deng Y, Ren Y, Wang R, Lu X, Guo J, Hu R, Virolle MJ, Xu D. | Front Microbiol | 2024 | | Streptomyces, Acetyltransferase, Acetylome, Bldkb, Sco0988 | 10.3389/fmicb.2024.1366336 | 39113837 | |
| TetR family regulator AbrT controls lincomycin production and morphological development in Streptomyces lincolnensis. | Xu Y, Liu M, Zhao R, Pan Y, Wu P, Zhang C, Chi X, Zhang B, Wu H. | Microb Cell Fact | 2024 | | Ligand, Streptomyces lincolnensis, Antibiotic Biosynthesis, Tetr Family Regulator, D-arabinose, Streptomyces, Lincomycin, Bacterial Proteins, Gene Expression Regulation, Bacterial | 10.1186/s12934-024-02498-8 | 39118116 | |
| Oxford Nanopore long read-based shotgun metagenomic data sets of simulated bacterial communities originating from fresh spinach and surface water. | Chen Z, Grim CJ, Ramachandran P, Meng J. | Microbiol Resour Announc | 2024 | Genetics | Pseudomonas aeruginosa, Salmonella Enterica, Sequencing Depth, Shotgun Metagenomics, Long Read, Oxford Nanopore Sequencing, Nanopore Chemistry, Simulated Community | 10.1128/mra.00586-24 | 39162465 | |
| The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds. | Buyachuihan L, Reiners S, Zhao Y, Grininger M. | Commun Chem | 2024 | | | 10.1038/s42004-024-01269-1 | 39181936 | |
| Impact of the Deletion of Genes of the Nitrogen Metabolism on Triacylglycerol, Cardiolipin and Actinorhodin Biosynthesis in Streptomyces coelicolor. | Abreu S, Lejeune C, David M, Chaminade P, Virolle MJ. | Microorganisms | 2024 | | Antibiotic, Oxidative stress, Cardiolipin, Triacylglycerol, Nitrogen Limitation | 10.3390/microorganisms12081560 | 39203402 | |
| Cryo-electron microscopy structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis. | Johnston HE, Batt SM, Brown AK, Savva CG, Besra GS, Futterer K. | Microbiology (Reading) | 2024 | | Mycobacterium tuberculosis, Cryoem, Polyketide Synthase, Mycolic Acid Synthesis, Mycobacterium tuberculosis, Mycolic Acids, Polyketide Synthases, Bacterial Proteins, Cryoelectron Microscopy | 10.1099/mic.0.001505 | 39412527 | |
| Sirtuin-dependent reversible lysine acetylation of the o-succinylbenzoyl-coenzyme A synthetase of Bacillus subtilis. | Burckhardt RM, Escalante-Semerena JC. | Microbiol Spectr | 2024 | Metabolism | Menaquinone Biosynthesis, Metabolic Stress, Gcn5-related Acetyltransferases, Bacillus Subtilis Metabolism, Osb-coa Synthetase, Proton Motive Force Control, Sirtuin Deacylase | 10.1128/spectrum.02011-24 | 39422507 | |
| Complete sequences of pIJ101-based Streptomyces-Escherichia coli shuttle vectors. | Brown KV, Nybo SE. | Access Microbiol | 2024 | | Streptomyces, Plasmid, Next-generation Sequencing, Synthetic Biology, Pij101 | 10.1099/acmi.0.000893.v3 | 39445316 | |
| Antioxidant and Pro-Oxidant Properties of Selected Clinically Applied Antibiotics: Therapeutic Insights. | Maliar T, Blazkova M, Polak J, Maliarova M, Urgeova E, Viskupicova J. | Pharmaceuticals (Basel) | 2024 | | Antibiotics, Oxidative stress, Antioxidant activity, Pro-oxidant Activity | 10.3390/ph17101257 | 39458897 | |
| Comparative study of lysine acetylation in Vesicomyidae clam Archivesica marissinica and the manila clam Ruditapes philippinarum: adaptation mechanisms in cold seep environments. | Kong X, Wang W, Chen S, Song M, Zhi Y, Cai Y, Zhang H, Shen X. | BMC Genomics | 2024 | | comparative proteomics, Post-translational modification, Lysine Acetylation, Adaptation Mechanism, Cold Seep Zone, Vesicomyidae Clam, Lysine, Bivalvia | 10.1186/s12864-024-10916-9 | 39465380 | |
| Transcriptomics-guided optimization of vitamins to enhance erythromycin yield in saccharopolyspora erythraea. | Ke X, Jiang X, Wang S, Tian X, Chu J. | Bioresour Bioprocess | 2024 | | Metabolic flux analysis, Saccharopolyspora erythraea, Metabolomics, erythromycin, vitamin, Transcriptomics | 10.1186/s40643-024-00817-w | 39485551 | |
| Highly parallel bending tests for fungal hyphae enabled by two-photon polymerization of microfluidic mold. | Brinkmann S, Schrader M, Meinen S, Kampen I, Kwade A, Dietzel A. | Front Bioeng Biotechnol | 2024 | | Aspergillus niger, Cell wall, Hyphae, Bending Stiffness, Two-photon Polymerization, Fungi-On-Chip | 10.3389/fbioe.2024.1449167 | 39553394 | |
| Glucose-1-phosphate thymidylyltransferase promotes the production of 3-O-alpha-mycarosylerythronolide B in Streptomyces coelicolor. | Gao H, Langer S, Larson T, Gregory MA, Smith MCM. | J Appl Microbiol | 2024 | | Streptomyces coelicolor, heterologous expression, erythromycin, Glucose-1-phosphate Thymidylyltransferase, Streptomyces coelicolor, Erythromycin | 10.1093/jambio/lxae291 | 39558883 | |
| Repurposing a Fully Reducing Polyketide Synthase toward 2-Methyl Guerbet-like Lipids. | Herrera MA, McColm S, Craigie LM, Simpson J, Brown F, Clarke DJ, Carr R, Campopiano DJ. | ACS Catal | 2024 | | | 10.1021/acscatal.4c04714 | 39569151 | |
| Engineering the TetR-family transcriptional regulator XNR_0706 to enhance heterologous spinosad production in Streptomyces albus B4 chassis. | Cui X, Tang H, Wang W, Wei W, Wu J, Ye BC. | Synth Syst Biotechnol | 2025 | Metabolism | heterologous expression, spinosad, Precursor Supply, Fatty Acids Metabolism, Tetr Family Transcriptional Regulator, Streptomyces Albus B4 | 10.1016/j.synbio.2024.08.008 | 39582691 | |
| Effect of TetR Family Transcriptional Regulator PccD on Phytosterol Metabolism of Mycolicibacterium. | Xiao P, Pan D, Li F, Liu Y, Huang Y, Zhou X, Zhang Y. | Microorganisms | 2024 | | Androstenedione, Metabolic regulation, Propionyl-coa, Mycolicibacterium Sp. Lz2, Transcription Factor Pccd | 10.3390/microorganisms12112349 | 39597737 | |
| Lrp Family Regulator SCAB_Lrp2 Responds to the Precursor Tryptophan and Represses the Thaxtomin Biosynthesis in Streptomyces scabies. | He H, Tang L, Song M, Chen H, Zou Y, Li X, Yang E, Wu H, Zhang B, Liu J. | Mol Plant Pathol | 2024 | | Tryptophan, Pathogenicity, Streptomyces scabies, Thaxtomin, Lrp Regulator, Streptomyces, Tryptophan, Bacterial Proteins, Gene Expression Regulation, Bacterial | 10.1111/mpp.70036 | 39617959 | |
| Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus. | Sarrazin M, Poncin I, Fourquet P, Audebert S, Camoin L, Denis Y, Santucci P, Spilling CD, Kremer L, Le Moigne V, Herrmann JL, Cavalier JF, Canaan S. | J Biomed Sci | 2024 | | Resistance, Mycobacterium Abscessus, Macrolide, Drug Susceptibility, Erm(41), Synergy Testing, Macrolides, Anti-Bacterial Agents, Mycobacterium abscessus | 10.1186/s12929-024-01091-w | 39623375 | |
| Metabolic Blockade-Based Genome Mining of Saccharopolyspora erythraea SCSIO 07745: Discovery and Biosynthetic Pathway of Aminoquinolinone Alkaloids Bearing 6/6/5 Tricyclic and 6/6/6/5 Tetracyclic Scaffolds. | Li K, Zhu H, Sun C, Tian G, Ma X, Saravana Kumar P, Weng X, Yang H, Fang R, Liu W, Shang Z, Ma J, Ju J. | Org Lett | 2025 | | Saccharopolyspora, Alkaloids, Quinolones | 10.1021/acs.orglett.4c04491 | 39705017 | |
| Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro. | Li K, Cho YI, Tran MA, Wiedemann C, Zhang S, Koweek RS, Hoang NK, Hamrick GS, Bowen MA, Kokona B, Stallforth P, Beld J, Hellmich UA, Charkoudian LK. | ACS Chem Biol | 2025 | | Polyketide Synthases, Acyl Carrier Protein, Protein Engineering | 10.1021/acschembio.4c00678 | 39745931 | |
| Succinylome Profiling the Function and Distribution of Lysine Succinylation in Saccharopolyspora erythraea. | Ke X, Jiang X, Hussain MH, Tian X, Chu J. | Appl Biochem Biotechnol | 2025 | | Saccharopolyspora erythraea, Post-translational modification, Lysine Succinylation, Succinylome, Saccharopolyspora, Succinic Acid, Lysine, Bacterial Proteins, Protein Processing, Post-Translational | 10.1007/s12010-024-05176-y | 39777642 | |
| In silico identification of silent primycin biosynthetic gene clusters within the family Pseudonocardiaceae. | Kovacs-Valasek M, Fekete C, Kovacs-Valasek A. | Heliyon | 2025 | Genetics | Structural genomics, Primycin Biosynthetic Gene Cluster - Pseudonocardiaceae | 10.1016/j.heliyon.2024.e41065 | 39801987 | |
| Exploring Tetraselmis chui microbiomes-functional metagenomics for novel catalases and superoxide dismutases. | Macdonald JFH, Han Y, Astafyeva Y, Bergmann L, Gurschke M, Dirksen P, Blumke P, Schneider YKH, Alawi M, Lippemeier S, Andersen JH, Krohn I. | Appl Microbiol Biotechnol | 2025 | Genetics | Superoxide dismutase, Catalase, Antioxidants, metagenome, Healthcare, Tetraselmis Chui, Microalgae Microbiome, Catalase, Superoxide Dismutase, Metagenomics, Chlorophyta, Microalgae, Microbiota | 10.1007/s00253-024-13395-w | 39804408 | |
| Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products. | Covington BC, Seyedsayamdost MR. | Nat Prod Rep | 2025 | | Biological Products, Mass Spectrometry, High-Throughput Screening Assays | 10.1039/d4np00026a | 39831433 | |
| The PurR family transcriptional regulator promotes butenyl-spinosyn production in Saccharopolyspora pogona. | Li X, Wang J, Su C, Guo C, Xu Z, Wang K, Pang J, Lv B, Wang C, Li C. | Appl Microbiol Biotechnol | 2025 | | Transcriptomic, Saccharopolyspora Pogona, Butenyl-spinosyn, Purr Family Transcriptional Regulator, Saccharopolyspora, Macrolides, Bacterial Proteins, Transcription Factors | 10.1007/s00253-024-13390-1 | 39836216 | |
| From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota. | Tahmasebi H, Arjmand N, Monemi M, Babaeizad A, Alibabaei F, Alibabaei N, Bahar A, Oksenych V, Eslami M. | Biomolecules | 2025 | | Evolution, Microbiota, Hospital-acquired Infections, Crisis, Antibiotic-resistant, Bacteria, Anti-Bacterial Agents, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Microbiota | 10.3390/biom15010093 | 39858487 | |
| Quantitative Proteomic Analysis of Lysine Malonylation in Response to Salicylic Acid in the Roots of Platycodon grandiflorus. | Ding W, Duan Y, Wang Y, Fan J, Rao W, Xing S. | Int J Mol Sci | 2025 | Proteome | Salicylic acid, Medicinal plants, Platycodon Grandiflorus, Post-translational modification, Lysine Malonylation, Qualitative Proteome, Platycodon, Plant Roots, Salicylic Acid, Lysine, Plant Proteins, Proteome, Proteomics | 10.3390/ijms26031392 | 39941159 | |
| Biosensor-based dual-color droplet microfluidic platform for precise high-throughput screening of erythromycin hyperproducers. | Zhao L, Li S, Yang Y, Qi L, Zhu Q, Zhao Y, Qi H, Liao X, Zhang Y, Wang M. | Biosens Bioelectron | 2025 | | High-throughput screening, Saccharopolyspora erythraea, erythromycin, Cell Heterogeneity, Whole-cell Biosensor, Droplet Microfluidic, Dual-color Screening, Escherichia coli, Erythromycin, Biosensing Techniques, High-Throughput Screening Assays | 10.1016/j.bios.2025.117376 | 40090258 | |
| A whole-genome study suggests a taxonomic rearrangement of Saccharopolyspora subtropica as a later heterotypic synonym of Saccharopolyspora thermophila and Saccharopolyspora spinosporotrichia as a later heterotypic synonym of Saccharopolyspora erythraea. | Dif G, Djemouai N, Meklat A, Zitouni A. | Int J Syst Evol Microbiol | 2025 | Genetics | Genomics, reclassification, Average Nucleotide Identity (Ani), Saccharopolyspora, Saccharopolyspora, Phylogeny, Genome, Bacterial | 10.1099/ijsem.0.006731 | 40153303 | Phylogeny |
| Enhanced Natamycin production in Streptomyces gilvosporeus through phosphate tolerance screening and transcriptome-based analysis of high-yielding mechanisms. | Wang L, Xiao W, Qiu T, Zhang H, Zhang J, Chen X. | Microb Cell Fact | 2025 | | Transcriptional regulation, Natamycin, Streptomyces gilvosporeus, Comparative Transcriptomics, Phosphate-tolerance Screening, Streptomyces, Phosphates, Natamycin | 10.1186/s12934-025-02696-y | 40176084 | |
| Protocol for the purification, analysis, and handling of acyl carrier proteins from type I fatty acid and polyketide synthases. | Gusenda C, Berlage S, Burkhart I, Chagot B, Weissman KJ, Schwalbe H, Grininger M. | STAR Protoc | 2025 | Enzymology | Molecular biology, NMR, Protein expression and purification, Biotechnology And Bioengineering, Polyketide Synthases, Acyl Carrier Protein | 10.1016/j.xpro.2025.103762 | 40220306 | Biotechnology |
| Calcium modulates growth and biofilm formation of Lactobacillus acidophilus ATCC 4356 and Lactiplantibacillus plantarum ATCC 14917. | Huynh U, King J, Zastrow ML. | Sci Rep | 2025 | | Biofilms, Lactobacillus acidophilus, Lactobacillus plantarum, Calcium | 10.1038/s41598-025-98577-w | 40274962 | |
| Integrated analysis of transcriptomics and metabolomics and high-throughput amplicon sequencing reveals the synergistic effects of secondary metabolites and rhizosphere microbiota on root rot resistance in Psammosilene tunicoides. | Yingtao L, Qiaofeng L, Lijuan W, Shuyun Q, Zhou J, Wenping Z, Aili Z. | Front Microbiol | 2025 | | Psammosilene tunicoides, Root rot, Plant Defense Mechanisms, Root Microbiome, Multi-omics | 10.3389/fmicb.2025.1554406 | 40297288 | |
| DNA origami-enhanced force spectroscopy and AlphaFold structural analyses reveal the folding landscape of calcium-binding proteins. | Zhang H, Canari-Chumpitaz C, Alexander L, Zhang H, Fan C, Bustamante C. | Sci Adv | 2025 | Proteome | Calcium-Binding Proteins, DNA, Protein Folding | 10.1126/sciadv.adv1962 | 40305599 | |
| Improving butenyl-spinosyn production in Saccharopolyspora pogona through combination of metabolic engineering and medium optimization. | Zhao X, Lu H, Peng S, Hang H, Aldahmash W, Al-Ghadi MQ, Tang W, Pei J, Xun W, Guo M, Mohsin A. | Front Microbiol | 2025 | Genetics | medium optimization, Targeted Metabolomic Analysis, Saccharopolyspora Pogona, Butenyl-spinosyn, Genomics-based Metabolic Engineering | 10.3389/fmicb.2025.1561042 | 40336833 | |
| dTSR enables efficient improvement of heterologous production of spinosad in Saccharopolyspora erythraea. | He W, Lu J, Bai L, Deng Z, Tao M. | Synth Syst Biotechnol | 2025 | | Site-specific recombination, heterologous expression, spinosad, Mini-transposon, Polyketide Natural Product, Tsr Strategy | 10.1016/j.synbio.2025.02.003 | 40337009 | |
| Redefining the role of the EryM acetyltransferase in natural product biosynthetic pathways. | Li Y, Liu X, Harris NR, Roberts JR, Valdivia EM, Ji X, Smith JL. | Structure | 2025 | | Biosynthesis, Natural products, Gcn5-related N-acetyltransferase, Erythrochelin, Saccharopolyspora, Acetyltransferases, Bacterial Proteins, Biological Products | 10.1016/j.str.2025.05.011 | 40516533 | |
| Karakum desert: a unique source of cultivable novel and rare actinomycetes with a remarkable biosynthetic potential. | Saygin H, Sahin N, Goodfellow M. | World J Microbiol Biotechnol | 2025 | Genetics | Biodiversity, Selective isolation, Stress Genes, Genome-mining, Biosynthetic Gene Clusters, Taxogenomics, Actinobacteria, Soil Microbiology | 10.1007/s11274-025-04399-3 | 40553312 | Phylogeny |
| Co-cultivation strategies for natural product discovery from actinomycetes: unlocking silent secondary metabolism with mycolic acid-containing bacteria. | Asamizu S. | World J Microbiol Biotechnol | 2025 | Metabolism | Co-culture, actinomycetes, secondary metabolism, Bacterial Interaction, Natural Product Discovery, Combined-culture, Actinobacteria, Mycolic Acids, Biological Products, Secondary Metabolism | 10.1007/s11274-025-04406-7 | 40555949 | |
| Metabolomic analysis of the impact of MtrA on carbon metabolism in Streptomyces coelicolor. | Zhu Y, Zhang H, Pang X. | Microbiol Spectr | 2025 | Metabolism | Streptomyces, Organic acid, Carbon metabolism, Mtra, Streptomyces coelicolor, Carbon, Bacterial Proteins, Transcription Factors | 10.1128/spectrum.00096-25 | 40586569 | |
| Tunable dynamic engineering of cellular NAD boosts the production of antibiotics in actinomycetes. | Wu P, Xu Z, Meng Z, Chen K, Lin H, Zhang M, Zhang L, Zhang B, Wu H. | Trends Biotechnol | 2025 | | Antibiotic, erythromycin, actinomycetes, Dynamic Regulation, Nad (Nicotinamide Adenine Dinucleotide), Actinobacteria, NAD, Anti-Bacterial Agents, Metabolic Engineering | 10.1016/j.tibtech.2025.06.003 | 40617717 | |
| Oxygen determines the requirement for cobalamin but not riboflavin in the growth of Propionibacterium freudenreichii. | Zhang R, Sha Y, Chamlagain B, Edelmann M, Savijoki K, Piironen V, Deptula P, Varmanen P. | Sci Rep | 2025 | | Oxygen, Vitamin B 12, Riboflavin, Propionibacterium freudenreichii | 10.1038/s41598-025-12983-8 | 40731039 | |
| Engineering the TCA cycle regulator GarA to increase erythromycin production in Saccharopolyspora erythraea. | Liuzzi AD, Tompkins HL, Pallett SK, Webster L, Mukamolova GV, Gregory MA, Sim M, O'Hare HM. | Microbiology (Reading) | 2025 | Metabolism | Protein kinase, Actinobacteria, TCA cycle, erythromycin, Polyketide Biosynthesis, Central Metabolism, Saccharopolyspora, Erythromycin, Bacterial Proteins, Anti-Bacterial Agents, Citric Acid Cycle, Metabolic Engineering | 10.1099/mic.0.001583 | 40758561 | |
| TrkA of Streptococcus mitis CCUG31611 binds cyclic di-adenosine monophosphate and is required for growth in low potassium conditions. | Vevik K, Sribasgaran B, Cai K, Naemi AO, Pedersen Kaspersen H, Uhlig S, Okstad OA, Simm R. | Microbiology (Reading) | 2025 | | Biofilm, Potassium Transport, Streptococcus Mitis, Dna Damage Stress, Cyclic Di-adenosine Monophosphate (C-di-amp), Trka Family Protein, Streptococcus mitis, Potassium, Bacterial Proteins, Dinucleoside Phosphates | 10.1099/mic.0.001597 | 40811027 | |
| Re-engineering a transferase scaffold for indole C3 methylation in diketopiperazines. | Haase M, Weiergraber OH, Pietruszka J. | Protein Sci | 2025 | | Crystal structure, Methyltransferase, Biocatalysis, rational design, Pyrroloindole Natural Product, Indoles, Methyltransferases, Bacterial Proteins, Protein Engineering, Diketopiperazines | 10.1002/pro.70254 | 40878043 | |
| Exploring extreme environments in Türkiye for novel P450s through metagenomic analysis. | Mumcu H, Zaugg J, Keles I, Kayrav A, Balci N, Nelson DR, Hugenholtz P, Gillam EMJ, Gul Karaguler N. | PLoS One | 2025 | Genetics | Cytochrome P-450 Enzyme System, Metagenome, Metagenomics, Extreme Environments | 10.1371/journal.pone.0330523 | 40920735 | |
| High-Frequency Microfluidic Fractionation for Compound-Resolved Bioactivity-Based Metabolomics. | Geibel C, Schubert J, Knoblauch SB, Hernandez A, Boldt L, Schneider DC, Papadopoulos Lambidis S, Vitale GA, Fleischer J, Haussmann M, Gross H, Wang M, Brotz-Oesterhelt H, Petras D. | Anal Chem | 2025 | | Anti-Bacterial Agents, Microfluidic Analytical Techniques, Metabolomics, Lab-On-A-Chip Devices | 10.1021/acs.analchem.5c04612 | 41138245 | |
| The Roles of Carbon-Nitrogen Synergy and Phosphate Regulation in Producing Higher Yield of Vancomycin by Amycolatopsis orientalis. | Mani V, Jeyachandran S, Aman M. | Microbiologyopen | 2025 | | Secondary metabolites, Media optimization, Vancomycin, Amycolatopsis orientalis, Production Media, Phosphates, Carbon, Nitrogen, Vancomycin, Anti-Bacterial Agents, Amycolatopsis | 10.1002/mbo3.70072 | 41159273 | |
| Comprehensive whole metagenomics analysis uncovers microbial community and resistome variability across anthropogenically contaminated soils in urban and suburban areas of Tamil Nadu, India. | Vasanthrao R, Nidhin IK, Taj Z, Chattopadhyay I. | Front Microbiol | 2025 | Genetics | Microbial diversity, Bioremediation, Virulence genes, Antibiotic resistance genes, metagenome, Heavy Metal Resistance Genes | 10.3389/fmicb.2025.1649872 | 41199948 | |
| Enhancing erythromycin production by Saccharopolyspora erythraea E3::sucBA in chemically defined medium. | Ke X, Wang S, Jiang X, Li X, Chu J, Tian X. | Bioresour Technol | 2025 | | Fermentation optimization, erythromycin, Chemically Defined Medium, Targeted Metabolomes | 10.1016/j.biortech.2025.133730 | 41317927 | |
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