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BacDive ID 186
Type strain
NCBI tax ID(s) 55565
Links
version 10 (current version)

General

@ref: 5989

BacDive-ID: 186

DSM-Number: 15540

keywords: 16S sequence, facultative anaerobe, mesophilic, Gram-positive, rod-shaped

description: Actinomyces graevenitzii DSM 15540 is a facultative anaerobe, mesophilic, Gram-positive prokaryote that was isolated from human bronchus brush, 57-yr-old woman.

NCBI tax id

  • NCBI tax id: 55565
  • Matching level: species

strain history

@refhistory
5989<- CCUG <- PHLS, Sweden
119721CIP <- 1998, CCUG <- Res. Dev., PHLS, Göteborg, Sweden

doi: 10.13145/bacdive186.20251217.10

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: kingdom/bacillati
  • keyword: phylum/actinomycetota
  • phylum: Actinomycetota
  • class: Actinomycetes
  • order: Actinomycetales
  • family: Actinomycetaceae
  • genus: Actinomyces
  • species: Actinomyces graevenitzii
  • full scientific name: Actinomyces graevenitzii Pascual Ramos et al. 1997

@ref: 5989

domain: Bacteria

phylum: Actinobacteria

class: Actinobacteria

order: Actinomycetales

family: Actinomycetaceae

genus: Actinomyces

species: Actinomyces graevenitzii

full scientific name: Actinomyces graevenitzii Pascual Ramos et al. 1997

type strain: yes

Morphology

cell morphology

@refgram staincell shapemotility
23120positiverod-shapedno
119721positiverod-shapedno

colony morphology

@refcolony sizeincubation periodmedium usedhemolysis ability
231200.2 mm1 dayblood agar
487022-3 days
1197211

pigmentation

  • @ref: 23120
  • production: no
  • name: no pigments

Culture and growth conditions

culture medium

@refnamegrowthlinkcomposition
5989FASTIDIOUS ANAEROBE AGAR (DSMZ Medium 1203)yeshttps://mediadive.dsmz.de/medium/1203Name: FASTIDIOUS ANAEROBE AGAR (DSMZ Medium 1203) Composition: Horse blood 100.0 g/l Fastidious Anaerobe Agar 45.7 g/l Distilled water
5989COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)yeshttps://mediadive.dsmz.de/medium/693Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
23120blood agaryes
39350MEDIUM 6 - Columbia agar with 10 % horse bloodyesDistilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)
119721CIP Medium 6yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=6

culture temp

@refgrowthtypetemperature
5989positivegrowth37
39350positivegrowth37
48702positivegrowth37
119721positivegrowth25-41
119721negativegrowth10
119721negativegrowth45

Physiology and metabolism

oxygen tolerance

@refoxygen tolerance
23120facultative anaerobe
48702microaerophile
119721facultative anaerobe

spore formation

  • @ref: 23120
  • spore formation: no

halophily

@refsaltgrowthtested relationconcentration
119721NaClpositivegrowth0-2 %
119721NaClnogrowth4 %
119721NaClnogrowth6 %
119721NaClnogrowth8 %
119721NaClnogrowth10 %

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
2312027613amygdalin-builds acid from
2312017057cellobiose-builds acid from
2312017108D-arabinose-builds acid from
2312018333D-arabitol-builds acid from
2312028847D-fucose-builds acid from
2312065327D-xylose-builds acid from
2312016813galactitol-builds acid from
2312017113erythritol-builds acid from
2312028066gentiobiose-builds acid from
2312028087glycogen-builds acid from
2312015443inulin-builds acid from
2312018403L-arabitol-builds acid from
2312018287L-fucose-builds acid from
2312017266L-sorbose-builds acid from
2312065328L-xylose-builds acid from
2312029864mannitol-builds acid from
231206731melezitose-builds acid from
2312028053melibiose-builds acid from
2312074863methyl beta-D-xylopyranoside-builds acid from
2312037657methyl D-glucoside-builds acid from
2312026546rhamnose-builds acid from
2312017814salicin-builds acid from
2312030911sorbitol-builds acid from
2312028017starch-builds acid from
2312027082trehalose-builds acid from
2312017151xylitol-builds acid from
231204853esculin-hydrolysis
23120606565hippurate-hydrolysis
2312016199urea-hydrolysis
2312017632nitrate-reduction
23120174265-dehydro-D-gluconate+builds acid from
2312016443D-tagatose+builds acid from
2312028757fructose+builds acid from
2312028260galactose+builds acid from
2312017754glycerol+builds acid from
2312017716lactose+builds acid from
2312017306maltose+builds acid from
2312017268myo-inositol+builds acid from
2312028037N-acetylgalactosamine+builds acid from
2312033942ribose+builds acid from
2312017992sucrose+builds acid from
6837917632nitrate-reduction
683794853esculin-hydrolysis
6837916199urea-hydrolysis
6837917634D-glucose+fermentation
6837965327D-xylose-fermentation
6837916899D-mannitol-fermentation
6837917306maltose+fermentation
6837917716lactose+fermentation
6837917992sucrose+fermentation
6837928087glycogen-fermentation
6837727897tryptophan-energy source
6837715824D-fructose+builds acid from
6837717306maltose+builds acid from
6837717634D-glucose+builds acid from
11972116947citrate-carbon source
1197214853esculin-hydrolysis
119721606565hippurate-hydrolysis
11972117632nitrate-reduction
11972116301nitrite-reduction
11972117632nitrate+respiration
68371Potassium 5-ketogluconate-builds acid from
6837128053melibiose-builds acid from
6837117992sucrose+builds acid from
6837117716lactose+builds acid from
6837118305arbutin-builds acid from
6837127613amygdalin-builds acid from
6837143943methyl alpha-D-mannoside-builds acid from
6837117924D-sorbitol-builds acid from
6837112936D-galactose-builds acid from
6837115963ribitol-builds acid from
68371Potassium 2-ketogluconate-builds acid from
6837124265gluconate-builds acid from
6837118403L-arabitol-builds acid from
6837118333D-arabitol-builds acid from
6837118287L-fucose-builds acid from
6837128847D-fucose-builds acid from
6837116443D-tagatose-builds acid from
6837162318D-lyxose-builds acid from
6837132528turanose+builds acid from
6837128066gentiobiose-builds acid from
6837117151xylitol-builds acid from
6837128087glycogen+builds acid from
6837128017starch+builds acid from
6837116634raffinose-builds acid from
683716731melezitose-builds acid from
6837115443inulin-builds acid from
6837127082trehalose-builds acid from
6837117306maltose+builds acid from
6837117057cellobiose-builds acid from
6837117814salicin-builds acid from
683714853esculin-builds acid from
6837159640N-acetylglucosamine-builds acid from
68371320061methyl alpha-D-glucopyranoside-builds acid from
6837116899D-mannitol-builds acid from
6837117268myo-inositol-builds acid from
6837116813galactitol-builds acid from
6837162345L-rhamnose-builds acid from
6837117266L-sorbose-builds acid from
6837116024D-mannose-builds acid from
6837115824D-fructose-builds acid from
6837117634D-glucose+builds acid from
6837165328L-xylose-builds acid from
6837165327D-xylose-builds acid from
6837116988D-ribose-builds acid from
6837130849L-arabinose-builds acid from
6837117108D-arabinose-builds acid from
6837117113erythritol-builds acid from
6837117754glycerol+builds acid from
6837716199urea-hydrolysis
6837718257ornithine-degradation
6837717992sucrose+builds acid from
6837174863methyl beta-D-xylopyranoside-builds acid from

antibiotic resistance

  • @ref: 119721
  • metabolite: 0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)
  • is antibiotic: yes
  • is sensitive: yes
  • is resistant: no

metabolite production

@refChebi-IDmetaboliteproduction
6837735581indoleno
11972135581indoleno

metabolite tests

@refChebi-IDmetaboliteindole testvoges-proskauer-testmethylred-test
6837735581indole-
11972115688acetoin-
11972117234glucose+

enzymes

@refvalueactivityec
23120acid phosphatase+3.1.3.2
23120alpha-fucosidase-3.2.1.51
23120alpha-galactosidase-3.2.1.22
23120alpha-glucosidase-3.2.1.20
23120alpha-mannosidase-3.2.1.24
23120beta-galactosidase+3.2.1.23
23120beta-glucosidase-3.2.1.21
23120beta-glucuronidase-3.2.1.31
23120chymotrypsin-3.4.4.5
23120leucine arylamidase+3.4.11.1
23120lipase-
23120N-acetyl-beta-glucosaminidase+3.2.1.52
23120phosphoamidase+3.9.1.1
23120pyrrolidonyl arylamidase-3.4.19.3
23120trypsin-3.4.21.4
23120valine arylamidase-
68382alkaline phosphatase-3.1.3.1
68382esterase (C 4)+
68382esterase lipase (C 8)+
68382lipase (C 14)-
68382leucine arylamidase+3.4.11.1
68382valine arylamidase-
68382cystine arylamidase-3.4.11.3
68382trypsin-3.4.21.4
68382alpha-chymotrypsin-3.4.21.1
68382acid phosphatase-3.1.3.2
68382naphthol-AS-BI-phosphohydrolase-
68382alpha-galactosidase-3.2.1.22
68382beta-galactosidase+3.2.1.23
68382beta-glucuronidase-3.2.1.31
68382alpha-glucosidase+3.2.1.20
68382beta-glucosidase-3.2.1.21
68382N-acetyl-beta-glucosaminidase+3.2.1.52
68382alpha-mannosidase-3.2.1.24
68382alpha-fucosidase-3.2.1.51
119721oxidase-
119721beta-galactosidase+3.2.1.23
119721alcohol dehydrogenase-1.1.1.1
119721gelatinase+/-
119721amylase+
119721DNase-
119721caseinase-3.4.21.50
119721catalase-1.11.1.6
119721tween esterase-
119721gamma-glutamyltransferase-2.3.2.2
119721lecithinase-
119721lipase-
119721lysine decarboxylase-4.1.1.18
119721ornithine decarboxylase-4.1.1.17
119721phenylalanine ammonia-lyase-4.3.1.24
119721protease-
119721tryptophan deaminase-
119721urease-3.5.1.5
68377tryptophan deaminase-4.1.99.1
68377gamma-glutamyltransferase-2.3.2.2
68377beta-galactosidase+3.2.1.23
68377lipase-
68379beta-glucosidase-3.2.1.21
68379beta-galactosidase+3.2.1.23
68379beta-glucuronidase-3.2.1.31
68377proline-arylamidase+3.4.11.5
68377urease-3.5.1.5
68377ornithine decarboxylase-4.1.1.17
68377beta-lactamase-3.5.2.6
68379catalase-1.11.1.6
68379urease-3.5.1.5
68379N-acetyl-beta-glucosaminidase+3.2.1.52
68379alkaline phosphatase-3.1.3.1
68379pyrrolidonyl arylamidase-3.4.19.3
68379pyrazinamidase+3.5.1.B15
68377alkaline phosphatase-3.1.3.1

API coryne

@refNITPYZPYRAPALbeta GURbeta GALalpha GLUbeta NAGESCUREGELControlGLURIBXYLMANMALLACSACGLYGCAT
48702-+---+-+----+---+++--
5989-+---+++--+-++/---+++-

API zym

@refControlAlkaline phosphataseEsteraseEsterase LipaseLipaseLeucine arylamidaseValine arylamidaseCystine arylamidaseTrypsinalpha- ChymotrypsinAcid phosphataseNaphthol-AS-BI-phosphohydrolasealpha- Galactosidasebeta- Galactosidasebeta- Glucuronidasealpha- Glucosidasebeta- GlucosidaseN-acetyl-beta- glucosaminidasealpha- Mannosidasealpha- Fucosidase
119721--++-+-------+-+-+--

API 50CHac

@refGLYERYDARALARARIBDXYLLXYLADOMDXGALGLUFRUMNESBERHADULINOMANSORMDMMDGNAGAMYARBESCSALCELMALLACMELSACTREINUMLZRAFAMDGLYGXLTGENTURLYXTAGDFUCLFUCDARLLARLGNT2KG5KG
119721+---------+----------------++-+----++--+---------

API NH

@refPENGLUFRUMALSACODCURELIPPALbeta GALProAGGTIND
48702-++++----++--

Isolation, sampling and environmental information

isolation

@refsample typegeographic locationcountryorigin.countrycontinentsampling dateisolation date
5989human bronchus brush, 57-yr-old womanGöteborgSwedenSWEEurope
48702Human bronchus brush,57-yr-old womanGöteborgSwedenSWEEurope1990-10-03
119721Human, Bronchus brushGöteborgSwedenSWEEurope1990

isolation source categories

Cat1Cat2Cat3
#Host#Human#Female
#Host Body-Site#Oral cavity and airways#Airways

taxonmaps

  • @ref: 69479
  • File name: preview.99_5454.png
  • url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_124;96_2643;97_3240;98_4073;99_5454&stattab=map
  • Last taxonomy: Actinomyces graevenitzii subclade
  • 16S sequence: AJ540309
  • Sequence Identity:
  • Total samples: 120006
  • soil counts: 1357
  • aquatic counts: 2309
  • animal counts: 115764
  • plant counts: 576

Interaction and safety

risk assessment

@refbiosafety levelbiosafety level comment
59892Risk group (German classification)
1197212Risk group (French classification)

Sequence information

16S sequences

@refdescriptionaccessionlengthdatabaseNCBI tax ID
23120A.graevenitzii sp. nov. 16S rRNA geneY095891360nuccore55565
5989Actinomyces graevenitzii 16S rRNA gene, strain CCUG 27294TAJ5403091413nuccore55565
124043Actinomyces graevenitzii CCUG 27294 gene for 16S rRNA, partial sequence.LC752337585nuccore55565

Literature

@ref: 5989

culture collection no.: DSM 15540, CCUG 27294, CIP 105737, CCM 4739

straininfo link

  • @ref: 126262
  • straininfo: 13434

literature

titleauthorsjournalyearmeshtopicPubmed-IDDOItopic2
The Infant Oral Microbiome: Developmental Dynamics, Modulating Factors, and Implications for Oral and Systemic HealthOlate P, Martinez A, Sans-Serramitjana E, Cortes M, Diaz R, Hernandez G, Paz E, Sepulveda N, Quinones J.Int J Mol Sci2025Nutrition, Oral Health, Infant Development, Oral Microbiome, Oral Dysbiosis
Actinomyces graevenitzii sp. nov., isolated from human clinical specimens.Ramos CP, Falsen E, Alvarez N, Akervall E, Sjoden B, Collins MDInt J Syst Bacteriol1997Actinomyces/*classification/genetics/*isolation & purification, Actinomycosis/*microbiology, DNA, Bacterial/analysis, DNA, Ribosomal/analysis, Humans, Molecular Sequence Data, PhylogenyPhylogeny922692410.1099/00207713-47-3-885Pathogenicity
Development of amplified 16S ribosomal DNA restriction analysis for identification of Actinomyces species and comparison with pyrolysis-mass spectrometry and conventional biochemical tests.Hall V, O'Neill GL, Magee JT, Duerden BI.J Clin Microbiol1999classification, genetics, genetics, geneticsPhylogeny1036459410.1128/jcm.37.7.2255-2261.1999
Genotypic diversity of clinical Actinomyces species: phenotype, source, and disease correlation among genospecies.Clarridge JE, Zhang Q.J Clin Microbiol2002classification, genetics, microbiology, physiopathology, Genetic VariationPhylogeny1220259110.1128/jcm.40.9.3442-3448.2002
Disseminated coinfection with Actinomyces graevenitzii and Mycobacterium tuberculosis: case report and review of the literature.Tietz A, Aldridge KE, Figueroa JE.J Clin Microbiol2005isolation & purification, isolation & purification, complications, complicationsEnzymology1595645010.1128/jcm.43.6.3017-3022.2005Phylogeny
Antimicrobial susceptibility testing of Actinomyces species with 12 antimicrobial agents.Smith AJ, Hall V, Thakker B, Gemmell CG.J Antimicrob Chemother2005drug effects, pharmacology, pharmacologyPathogenicity1597231010.1093/jac/dki206
Actinomyces--gathering evidence of human colonization and infection.Hall V.Anaerobe2008microbiology, growth & development, isolation & purification, microbiology, microbiologyEnzymology1822271410.1016/j.anaerobe.2007.12.001Phylogeny
Thoracic vertebral actinomycosis: Actinomyces israelii and Fusobacterium nucleatum.Honda H, Bankowski MJ, Kajioka EH, Chokrungvaranon N, Kim W, Gallacher ST.J Clin Microbiol2008microbiology, complications, complications, microbiology1833738510.1128/jcm.01706-07
Proximal small intestinal microbiota and identification of rod-shaped bacteria associated with childhood celiac disease.Ou G, Hedberg M, Horstedt P, Baranov V, Forsberg G, Drobni M, Sandstrom O, Wai SN, Johansson I, Hammarstrom ML, Hernell O, Hammarstrom S.Am J Gastroenterol2009microbiology, microbiology, classification, microbiologyPhylogeny1975597410.1038/ajg.2009.524
Actinomyces graevenitzii bacteremia in a patient with alcoholic liver cirrhosis.Hwang SS, Park SD, Jang IH, Uh Y, Yoon KJ, Kim HY.Anaerobe2011isolation & purification, diagnosis, diagnosis, complicationsEnzymology2142106910.1016/j.anaerobe.2011.03.002Phylogeny
Pulmonary actinomycosis complicating infliximab therapy for Crohn disease.Cohen R, Bowie W, Enns R, Flint J, Fitzgerald M.BMJ Case Rep20092168638410.1136/bcr.11.2008.1262
Divergent pro-inflammatory profile of human dendritic cells in response to commensal and pathogenic bacteria associated with the airway microbiota.Larsen JM, Steen-Jensen DB, Laursen JM, Sondergaard JN, Musavian HS, Butt TM, Brix S.PLoS One2012immunology, immunology, microbiology, immunology, immunology, immunology2236377810.1371/journal.pone.0031976
Multiple lung abscesses caused by Actinomyces graevenitzii mimicking acute pulmonary coccidioidomycosis.Nagaoka K, Izumikawa K, Yamamoto Y, Yanagihara K, Ohkusu K, Kohno S.J Clin Microbiol2012isolation & purification, diagnosis, pathology, diagnosis, pathologyEnzymology2276004910.1128/jcm.00761-12Phylogeny
Intestinal T-cell responses in celiac disease - impact of celiac disease associated bacteria.Sjoberg V, Sandstrom O, Hedberg M, Hammarstrom S, Hernell O, Hammarstrom ML.PLoS One2013immunology, immunology, pathology, immunology, immunology, microbiology2332642510.1371/journal.pone.0053414
Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study.Gao W, Weng J, Gao Y, Chen X.BMC Infect Dis2013microbiology, virology, isolation & purification, microbiologyEnzymology2375885710.1186/1471-2334-13-271Phylogeny
Genome resolved analysis of a premature infant gut microbial community reveals a Varibaculum cambriense genome and a shift towards fermentation-based metabolism during the third week of life.Brown CT, Sharon I, Thomas BC, Castelle CJ, Morowitz MJ, Banfield JF.Microbiome20132445118110.1186/2049-2618-1-30
The first 1000 cultured species of the human gastrointestinal microbiota.Rajilic-Stojanovic M, de Vos WM.FEMS Microbiol Rev2014Function, Diversity, Gut, Microbiota, Gastrointestinal, Microbiome, microbiology, parasitology, physiology, Biodiversity, Bacterial Physiological Phenomena, physiology2486194810.1111/1574-6976.12075
Staphylococcus lugdunensis: Novel Organism causing Cochlear Implant Infection.Bhumbra S, Mahboubi M, Blackwood RA.Infect Dis Rep2014Cochlear implant, Coagulase Negative Staphylococcus, Staphylococcus Lugdunensis2500296210.4081/idr.2014.5406
Pseudo-outbreak of Actinomyces graevenitzii associated with bronchoscopy.Peaper DR, Havill NL, Aniskiewicz M, Callan D, Pop O, Towle D, Boyce JM.J Clin Microbiol2015classification, microbiology, epidemiology, Cross Infection, adverse effects, Equipment ContaminationPhylogeny2535576710.1128/jcm.02302-14
Actinomyces graevenitzii pulmonary abscess mimicking tuberculosis in a healthy young man.Gliga S, Devaux M, Gosset Woimant M, Mompoint D, Perronne C, Davido B.Can Respir J20142549359110.1155/2014/841480
Rapid identification of oral Actinomyces species cultivated from subgingival biofilm by MALDI-TOF-MS.Stingu CS, Borgmann T, Rodloff AC, Vielkind P, Jentsch H, Schellenberger W, Eschrich K.J Oral Microbiol2015MALDI-TOF-MS, Support vector machine, Oral Actinomyces2559730610.3402/jom.v7.26110
Actinomyces and related organisms in human infections.Kononen E, Wade WG.Clin Microbiol Rev2015physiology, microbiology2578851510.1128/cmr.00100-14
A Pilot Study to Evaluate the Oral Microbiome and Dental Health in Primary Open-Angle Glaucoma.Polla D, Astafurov K, Hawy E, Hyman L, Hou W, Danias J.J Glaucoma2017microbiology, epidemiology, microbiology, complications2782042510.1097/ijg.0000000000000465
Salivary Microbiome Diversity in Caries-Free and Caries-Affected Children.Jiang S, Gao X, Jin L, Lo EC.Int J Mol Sci2016Saliva, Etiology, Children, 16S rRNA gene, Microbiome, Early Childhood Caries, microbiology, microbiologyPhylogeny2789802110.3390/ijms17121978
Antimicrobial susceptibility of clinical isolates of Actinomyces and related genera reveals an unusual clindamycin resistance among Actinomyces urogenitalis strains.Barberis C, Budia M, Palombarani S, Rodriguez CH, Ramirez MS, Arias B, Bonofiglio L, Famiglietti A, Mollerach M, Almuzara M, Vay C.J Glob Antimicrob Resist2017Clindamycin, Antimicrobial Susceptibility, Actinomyces Spp., drug effects, isolation & purification, microbiology, pharmacology, pharmacology, Drug Resistance, BacterialPathogenicity2810984610.1016/j.jgar.2016.11.007Enzymology
MetaSort untangles metagenome assembly by reducing microbial community complexity.Ji P, Zhang Y, Wang J, Zhao F.Nat Commun2017microbiology, genetics, Software, Metagenome, methods, geneticsGenetics2811217310.1038/ncomms14306
Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma.Lopes Dos Santos Santiago G, Brusselle G, Dauwe K, Deschaght P, Verhofstede C, Vaneechoutte D, Deschepper E, Jordens P, Joos G, Vaneechoutte M.BMC Microbiol2017Asthma, azithromycin, Antibiotic Treatment, Oral Microbiome, Oropharyngeal Microbiome, microbiology, drug effects, complications, therapeutic use, drug effectsPathogenicity2848693310.1186/s12866-017-1022-6
Targeted next-generation sequencing of the 16S-23S rRNA region for culture-independent bacterial identification - increased discrimination of closely related species.Sabat AJ, van Zanten E, Akkerboom V, Wisselink G, van Slochteren K, de Boer RF, Hendrix R, Friedrich AW, Rossen JWA, Kooistra-Smid AMDM.Sci Rep2017microbiology, urine, methods, methods2861140610.1038/s41598-017-03458-6
A 79-Year-Old Man With Chronic Aspiration and an 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computerized Tomography Positive Lung Mass.Ramanan P, Qureshi AS, Martin SA, Zea D, Patel R, Pritt BS.Open Forum Infect Dis2017Actinomyces, Pulmonary2870246610.1093/ofid/ofw256
Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells.Pietz G, De R, Hedberg M, Sjoberg V, Sandstrom O, Hernell O, Hammarstrom S, Hammarstrom ML.PLoS One2017immunology, immunology, immunology, immunology, metabolism, metabolismMetabolism2893429410.1371/journal.pone.0185025
Host genetic variation and its microbiome interactions within the Human Microbiome Project.Kolde R, Franzosa EA, Rahnavard G, Hall AB, Vlamakis H, Stevens C, Daly MJ, Xavier RJ, Huttenhower C.Genome Med2018Association Studies, Human Microbiome Project, Human Genome Sequence, Microbiome And Human Genetics, Microbiome Metagenome Sequence, Genetic Variation, geneticsGenetics2937863010.1186/s13073-018-0515-8
Meta-analysis of the lung microbiota in pulmonary tuberculosis.Hong BY, Paulson JN, Stine OC, Weinstock GM, Cervantes JL.Tuberculosis (Edinb)2018Tuberculosis, Lung, Microbiota, Meta-analysis, microbiology, isolation & purification, microbiology, microbiology, MicrobiotaEnzymology2955911310.1016/j.tube.2018.02.006Phylogeny
Pulmonary Actinomyces graevenitzii Infection Diagnosed by Bronchoscopy using Endobronchial Ultrasonography with a Guide Sheath.Himeji D, Hara S, Kawaguchi T, Tanaka GI.Intern Med2018Bronchoscopy, Endobronchial Ultrasonography With A Guide Sheath (Ebus-gs), Pulmonary Actinomycosis, Actinomyces Graevenitzii, diagnosis, diagnosis, methods2970995910.2169/internalmedicine.9799-17
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The Composition and Metabolic Potential of the Human Small Intestinal Microbiota Within the Context of Inflammatory Bowel Disease.Ruigrok RAAA, Collij V, Sureda P, Klaassen MAY, Bolte LA, Jansen BH, Voskuil MD, Fu J, Wijmenga C, Zhernakova A, Weersma RK, Vich Vila A.J Crohns Colitis2021Shotgun sequencing, Inflammatory Bowel Disease, Small Intestinal Microbiota, microbiology, Inflammatory Bowel Diseases, Gastrointestinal Microbiome3351500810.1093/ecco-jcc/jjab020
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Results from a pilot study on the oral microbiome in children and adolescents with chronic nonbacterial osteomyelitis.Zeus M, Janssen S, Laws HJ, Fischer U, Borkhardt A, Oommen PT.Z Rheumatol2023Children, Microbiome, Autoinflammation, Cno, Osteomyelitis, MicrobiotaPathogenicity3419679410.1007/s00393-021-01035-x
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Disentangling the Progression of Non-alcoholic Fatty Liver Disease in the Human Gut Microbiota.Wang T, Guo XK, Xu H.Front Microbiol2021Liver fibrosis, Meta-analysis, Liver cirrhosis, Microbiome, Nafld3472132610.3389/fmicb.2021.728823
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Tooth Loss and Risk of Lung Cancer among Urban Chinese Adults: A Cohort Study with Meta-Analysis.Yoon HS, Shu XO, Gao YT, Yang G, Cai H, Shi J, Yang JJ, Rothman N, Lan Q, Zheng W, Cai Q.Cancers (Basel)2022Lung cancer, Meta-analysis, Smoking, Prospective study, Tooth loss, Oral Health3562603610.3390/cancers14102428
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Saliva microbiome, dietary, and genetic markers are associated with suicidal ideation in university students.Ahrens AP, Sanchez-Padilla DE, Drew JC, Oli MW, Roesch LFW, Triplett EW.Sci Rep2022Suicidal Ideation, Microbiota3599596810.1038/s41598-022-18020-2
Clostridium butyricum Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care.Liu L, Chen X, Liu L, Qin H.Nutrients2022Metabolism, Probiotic, Elderly people, metagenome, Clostridium butyricum, Malnutrition, MicrobiotaMetabolism3607980610.3390/nu14173546Genetics
Features of the oral microbiome in Japanese elderly people with 20 or more teeth and a non-severe periodontal condition during periodontal maintenance treatment: A cross-sectional study.Toyama N, Ekuni D, Yokoi A, Fukuhara D, Islam MM, Sawada N, Nakashima Y, Nakahara M, Sumita I, Morita M.Front Cell Infect Microbiol2022Bacteria, Diversity, Elderly people, Oral Microbiome, Non-Severe Periodontal Condition, Periodontal Diseases, Periodontitis, Microbiota3627503010.3389/fcimb.2022.957890
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Oral Microcosm Biofilms Grown under Conditions Progressing from Peri-Implant Health, Peri-Implant Mucositis, and Peri-Implantitis.Sousa V, Spratt D, Davrandi M, Mardas N, Beltran V, Donos N.Int J Environ Res Public Health2022Therapy, Microcosm, Microbial ecology, Microbiome, Oral Biofilm, Peri-implantitis, Modelling Biofilms, Mucositis, Peri-Implantitis, Microbiota3636097010.3390/ijerph192114088
Actinomyces and Shewanella algae complicated paediatric mastoiditis: a case report of a multidisciplinary approach.Martins Sousa M, von Hafe M, Reis-Melo A, Silveira H, Coutinho G, Moura CP.Access Microbiol2022Mastoiditis, Actinomycosis, Acute Otitis Media, Shewanella3664473510.1099/acmi.0.000436
The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients.Krzysciak W, Karcz P, Bystrowska B, Szwajca M, Bryll A, Smierciak N, Ligezka A, Turek A, Kozicz T, Skalniak AE, Jagielski P, Popiela TJ, Pilecki M.Biomedicines2023Schizophrenia, Oral Microbiota, Brain Lactate3683077710.3390/biomedicines11020240
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Altered oral microbiome in Sudanese Toombak smokeless tobacco users carries a newly emerging risk of squamous cell carcinoma development and progression.Sami A, Elimairi I, Ryan CA, Stanton C, Patangia D, Ross RP.Sci Rep2023Tobacco, Smokeless, Carcinoma, Squamous Cell, Mouth Neoplasms, Precancerous Conditions, Microbiota3709511210.1038/s41598-023-32892-y
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Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity.Raju SC, Molinaro A, Awoyemi A, Jorgensen SF, Braadland PR, Nendl A, Seljeflot I, Ueland PM, McCann A, Aukrust P, Vestad B, Mayerhofer C, Broch K, Gullestad L, Lappegard KT, Halvorsen B, Kristiansen K, Hov JR, Troseid M.Genome Med2024Inflammation, Heart Failure, Gut Microbiota, Imidazole Propionate, Heart Failure, MicrobiotaPathogenicity3833189110.1186/s13073-024-01296-6
Detailed Characterization of the Lung-Gut Microbiome Axis Reveals the Link between PD-L1 and the Microbiome in Non-Small-Cell Lung Cancer Patients.Ankudavicius V, Nikitina D, Lukosevicius R, Tilinde D, Salteniene V, Poskiene L, Miliauskas S, Skieceviciene J, Zemaitis M, Kupcinskas J.Int J Mol Sci2024Lung cancer, Microbiota, PD-L1, Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Gastrointestinal Microbiome3839699810.3390/ijms25042323
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Chlorhexidine digluconate mouthwash alters the oral microbial composition and affects the prevalence of antimicrobial resistance genes.Bartsch S, Kohnert E, Kreutz C, Woelber JP, Anderson A, Burkhardt AS, Hellwig E, Buchalla W, Hiller KA, Ratka-Krueger P, Cieplik F, Al-Ahmad A.Front Microbiol2024Antibiotics, Tetracycline, Cross-resistance, Efflux pump, Streptococci, metagenome, Caries, ChlorhexidineGenetics3898363410.3389/fmicb.2024.1429692
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Active herpesviruses are associated with intensive care unit (ICU) admission in patients pulmonary infection and alter the respiratory microbiome.Liu Z, Qi CJ, Shi Y, Li T, Fang Y, Zhang Q.Front Microbiol2024Pulmonary infection, metagenome, Herpesviruses, Icu Patients, Respiratory MicrobiomeGenetics3918402710.3389/fmicb.2024.1441476
Genetic Patterns of Oral Cavity Microbiome in Patients with Sickle Cell Disease.Al-Sarraj F, Albiheyri R, Qari M, Alotaibi M, Al-Zahrani M, Anwar Y, Alghamdi MA, Nass NM, Bouback T, Alotibi I, Radhwi O, Sajer BH, Redhwan A, Al-Matary MA, Almanzalawi EA, Elshafie HS.Int J Mol Sci2024Next-generation Sequencing, Metagenomics, Sickle Cell Anemia, Systemic Diseases, Mouth, Saliva, Anemia, Sickle Cell, RNA, Ribosomal, 16S, MicrobiotaGenetics3920125810.3390/ijms25168570Phylogeny
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Functional metagenomics highlights varied infection states with dynamics of pathogens and antibiotic resistance in lower respiratory tract infections.Shamim U, Yadav A, Maurya R, Devi P, Kumari P, Kanika, Khare K, Tarai B, Pandey R.Heliyon2024Microbes, Pneumonia, Antimicrobial Resistance (Amr), Lower Respiratory Tract Infection (Lrti), Metagenomic Next-generation Sequencing (Mngs), Czid Seq, Explify, Rpip3941681610.1016/j.heliyon.2024.e38380
SARS-CoV-2 infection elucidates features of pregnancy-specific immunity.Oh DS, Kim E, Normand R, Lu G, Shook LL, Lyall A, Jasset O, Demidkin S, Gilbert E, Kim J, Akinwunmi B, Tantivit J, Tirard A, Arnold BY, Slowikowski K, MGH COVID-19 Collection & Processing Team, Goldberg MB, Filbin MR, Hacohen N, Nguyen LH, Chan AT, Yu XG, Li JZ, Yonker L, Fasano A, Perlis RH, Pasternak O, Gray KJ, Choi GB, Drew DA, Sen P, Villani AC, Edlow AG, Huh JR.Cell Rep2024Pregnancy, Cytokines, T cells, Immune cells, Immune responses, Maternal Immune Activation, Single-cell Rna-seq, Covid-19, Sars-cov-2, Cp: Immunology, CD8-Positive T-Lymphocytes, Pregnancy Complications, Infectious, Cytokines, COVID-19, SARS-CoV-23950424110.1016/j.celrep.2024.114933
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Comprehensive human respiratory genome catalogue underlies the high resolution and precision of the respiratory microbiome.Li Y, Pan G, Wang S, Li Z, Yang R, Jiang Y, Chen Y, Li SC, Shen B.Brief Bioinform2024Microbial Etiology, Respiratory Microbiome, Metagenomic Assembly, Human Respiratory Genome Catalogue, MicrobiotaGenetics3958187410.1093/bib/bbae620
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Lung Microbiome in Lung Cancer: A Systematic Review.Lucaciu SR, Domokos B, Puiu R, Ruta V, Motoc SN, Rajnoveanu R, Todea D, Stoia AM, Man AM.Microorganisms2024Lung cancer, Lung Microbiome3977064210.3390/microorganisms12122439
Classification of NSCLC subtypes using lung microbiome from resected tissue based on machine learning methods.Kashyap P, Raj KV, Sharma J, Dutt N, Yadav P.NPJ Syst Biol Appl2025Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Microbiota, Machine Learning3982487910.1038/s41540-025-00491-4
Potential roles of cigarette smoking on gut microbiota profile among Chinese men.Fan J, Zeng F, Zhong H, Cai J, Shen W, Cheng C, He C, Liu Y, Zhou Y, Chen S, Zhu Y, Liu T, Zheng JS, Wang L, Chen YM, Ma W, Zhou D.BMC Med2025Chinese, Cigarette smoking, Gut Microbiota, Male Population, Gastrointestinal Microbiome, Cigarette Smoking3983836910.1186/s12916-025-03852-2
Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China.Qu Q, Dou Q, Xiang Z, Yu B, Chen L, Fan Z, Zhao X, Yang S, Zeng P.NPJ Biofilms Microbiomes2025Bacteria, Metabolic Diseases, Gastrointestinal Microbiome3990503810.1038/s41522-025-00661-6
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ACE inhibitory casein peptide lowers blood pressure and reshapes gut microbiota in a randomized double blind placebo controlled trial.Li K, Jiang P, Li S, Sun J, Qi C.Sci Rep2025Hypertension, Casein hydrolysate, Microbiota, Antihypertensive Effect, Double-blind Randomized Placebo-controlled Clinical Study, Hypertension, Caseins, Antihypertensive Agents, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Gastrointestinal Microbiome4026351310.1038/s41598-025-98446-6
Multi-year comparison of VITEK MS performance for identification of rarely encountered pathogenic gram-positive organisms (GPOs) in a large integrated Canadian healthcare region.Church D, Griener T, Gregson D.Microbiol Spectr2025Identification, Gram-positive bacteria, MALDI-TOF, Vitek Ms, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Bacterial Typing Techniques4027217010.1128/spectrum.02545-24
Distal gut colonization by oral bacteria during intensive chemotherapy: direct evidence from strain-level analysis of paired samples.Raychaudhuri S, Gem H, Chung K, McLean JS, Kerns KA, Hullar MAJ, Elmorr E, Appelbaum JB, Percival MM, Walter RB, Halpern AB, Minot SS, Kim K, Zevin AS, Rashidi A.NPJ Biofilms Microbiomes2025Mouth, Bacteria, Antineoplastic Agents, Gastrointestinal Microbiome4041951310.1038/s41522-025-00725-7
Altered microbiota of the lower respiratory tract and its association with COVID-19 severity analysed by metagenomics and metatranscriptomics.Wang D, Duan Y, He L, Jiang J, Xian J, Yuan K, Zhang R, Zhang H, Wang J, Li N, Huang M, Hu C, Lu S, Luo Z, Deng T, Zhang Z, Chen B, Li W.Commun Biol2025Respiratory System, Microbiota, COVID-19, SARS-CoV-24041979010.1038/s42003-025-08234-1
Differences of the respiratory microbiota between children suffering from community acquired pneumonia with presence or absence of asthma.Chen L, Chen H, Lv T, Guo X, Wu W, Zhao D, Liu F.Sci Rep2025Pathogen, Asthma, Community-acquired pneumonia, Respiratory Microbiota, Metagenomic Second-generation Sequencing, Community-Acquired Infections, Asthma, Pneumonia, Microbiota4059397910.1038/s41598-025-04847-y
A Pulmonary Abscess Caused by Porphyromonas gingivalis Infection: A Case Report and Literature Review.Chen X, Wu L, Wu R, Dong J.Clin Respir J2025Porphyromonas gingivalis, Periodontitis, Lung abscess, Porphyromonas gingivalis, Bacteroidaceae Infections, Lung Abscess4066760010.1111/crj.70099
Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach.Ma H, Wang M, Feng Y, Zhang W, Wang W, Xie Y, Kong G, Feng J, Wang P, Wang Q, Huang X.FEBS Open Bio2025Acute Appendicitis, Microbial Profile, Shotgun Metagenomic Sequencing, Appendix Niche, Endoscopic Retrograde Appendicitis Treatment4084746210.1002/2211-5463.70105
Diagnosis of Pulmonary Actinomycosis Caused by Actinomyces graevenitzii: a Case Series of Three Patients.Zhang X, He Q, Mao G, Liang M.Clin Lab2025Actinomyces, Actinomycosis, Lung Diseases4092373610.7754/clin.lab.2025.250254
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Oral Microbiota Dysbiosis in Male HIV Patients: Comparative Analysis of Candidiasis and HPV-Associated Lesions.Ramirez-Hernandez MDC, Gaytan-Cervantes J, Gonzalez-Torres C, Loyola-Cruz MA, Garcia-Mendiola RE, Cruz-Cruz C, Cortes-Ortiz IA, Garcia-Moncada E, Lopez-Flores T, Duran-Manuel EM, Gomez-Mancilla N, Oviedo-Lopez MF, Jimenez-Zamarripa CA, Rojas-Bernabe A, Garcia-Hernandez OA, Puente-Rivera J, Lopez-Ornelas A, Nieto-Velazquez NG, Blanco-Hernandez DMR, Castaneda-Ortega JC, Hernandez-Castellanos B, Anaya-Saavedra G, Calzada-Mendoza CC, Bello-Lopez JM.Microorganisms2025HIV, Oral Lesions, Oral Microbiota, Massive Sequencing4101145210.3390/microorganisms13092121
Differential microbiome response to sucrose in caries-free and caries-affected individuals.Wang Y, Liu X, Ma S, Li L, Wang L.AMB Express2025Saliva, Sucrose, 16S rRNA, dental caries, Oral MicrobiomePhylogeny4109137810.1186/s13568-025-01943-0
Dysbiosis of the oropharyngeal microbiota in COVID-19: distinct profiles in patients with severe respiratory symptoms.Kumari V S S, Potdar V, Shinde M, Parashar D, Alagarasu K, Cherian S, Lavania M.J Oral Microbiol2025Disease severity, Metagenomics, Oropharyngeal Microbiota, Covid-19, Sars-cov-2Genetics4111249110.1080/20002297.2025.2569523

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5989Curators of the DSMZLeibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 15540)https://www.dsmz.de/collection/catalogue/details/culture/DSM-15540
20215Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.10.1099/ijsem.0.004332List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
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39350Curators of the CIPhttps://brclims.pasteur.fr/brcWeb/souche/detail/1/17790
48702Curators of the CCUGCulture Collection University of Gothenburg (CCUG) (CCUG 27294)https://www.ccug.se/strain?id=27294
68371Automatically annotated from API 50CH acid
68377Automatically annotated from API NH
68379Automatically annotated from API Coryne
68382Automatically annotated from API zym
69479João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.https://microbeatlas.org/MicrobeAtlas 1.0 beta
119721Curators of the CIPCollection of Institut Pasteur (CIP 105737)https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%20105737
124043Isabel Schober, Julia KoblitzData extracted from sequence databases, automatically matched based on designation and taxonomy
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